A theoretical characterization of reactions of HOOO radical with guanine: formation of 8-oxoguanine
K Bhattacharjee, PK Shukla - Structural Chemistry, 2018 - Springer
… reactions of prominent ROS such as OH radical, OOH radical… in these reactions can lead to
harmful consequences such as … mechanisms of reactions of HOOO radical with guanine (G). …
harmful consequences such as … mechanisms of reactions of HOOO radical with guanine (G). …
Formation and repair of oxidatively generated damage in cellular DNA
J Cadet, KJA Davies, MHG Medeiros… - Free Radical Biology …, 2017 - Elsevier
… H 2 O 2 according to the Fenton reaction giving rise to highly reactive hydroxyl radicals ( •
OH) … mechanism through energy transfer from triplet excited molecules to molecular oxygen. …
OH) … mechanism through energy transfer from triplet excited molecules to molecular oxygen. …
Computational Investigation into the Oxidation of Guanine to Form Imidazolone (Iz) and Related Degradation Products
SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2020 - ACS Publications
… Cadet and co-workers investigated the mechanism for Iz formation via riboflavin photooxidation
… be formed by reaction of molecular oxygen with a transient intermediate radical, or as an …
… be formed by reaction of molecular oxygen with a transient intermediate radical, or as an …
Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation
J Cadet, D Angelov, JR Wagner - International Journal of …, 2022 - Taylor & Francis
… mechanism for the formation of 2Ih involving initial • OH addition to Gua at C5. This is
problematic for two … , it was found that one-electron oxidation reactions of nucleobases lead to a …
problematic for two … , it was found that one-electron oxidation reactions of nucleobases lead to a …
Does 8-Nitroguanine Form 8-Oxoguanine? An Insight from Its Reaction with •OH Radical
K Bhattacharjee, PK Shukla - The Journal of Physical Chemistry B, 2018 - ACS Publications
… the mechanism of reaction of • OH radical with 8-nitroG leading to the formation of 8-oxoguanine
(8-oxoG) (one … for the formation of 8-oxoG due to reaction of • OH radical with 8-nitroG. …
(8-oxoG) (one … for the formation of 8-oxoG due to reaction of • OH radical with 8-nitroG. …
Computational study of the oxidation of guanine to form 5-carboxyamido-5-formamido-2-iminohydantoin (2Ih)
SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2019 - ACS Publications
… a C4–C5 epoxide, which leads to 2Ih by an alternate mechanism. (47) … 3 to Grad is the
dominant step after C4 addition of OH radical. … found Sp and Iz as the dominant reaction products. …
dominant step after C4 addition of OH radical. … found Sp and Iz as the dominant reaction products. …
Exploring the mechanisms for the radical induced damage of 6‐thioguanine
L Sandhiya, K Senthilkumar - International Journal of Quantum …, 2018 - Wiley Online Library
… The reaction of OH radical with DNA nucleobases has been studied extensively using density
… The formation of 8-oxoguanine or 8-nitroguanine due to the addition reactions of various …
… The formation of 8-oxoguanine or 8-nitroguanine due to the addition reactions of various …
Theoretical insight into 7, 8-dihydrogen-8-oxoguanine radical cation deprotonation
S Wei, Z Zhang, S Liu, Y Wang - New Journal of Chemistry, 2021 - pubs.rsc.org
… G encounters hydroxyl radicals, singlet oxygen, or one-electron … the mechanisms of 8-oxoG
+ deprotonation reaction, 15 … This may be due to the fact that the hydration models built in …
+ deprotonation reaction, 15 … This may be due to the fact that the hydration models built in …
[HTML][HTML] 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
… hydroxyl radicals, superoxide, and hydrogen peroxide (H 2 O … quality control, and regulatory
mechanisms for redox-mediated … reaction, LSD1 generates local ROS (H 2 O 2 ) that lead to …
mechanisms for redox-mediated … reaction, LSD1 generates local ROS (H 2 O 2 ) that lead to …
On the relevance of hydroxyl radical to purine DNA damage
… Hydroxyl radicals (HO • ) are the most reactive species … reaction mechanism, involving the
production of HO • radical … , the DNA glycosylase which removes 8-oxoguanine in G:C pairs, a …
production of HO • radical … , the DNA glycosylase which removes 8-oxoguanine in G:C pairs, a …