Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation

JY Kim, P Stevens, M Karpurapu, H Lee… - Frontiers in …, 2022 - frontiersin.org
… Although several mediators have been implicated in neutrophil … -155 could be targeted to
decrease allergic lung inflammation by … DNase I instillation decreased the intensity of airway …

Mesenchymal stromal cell apoptosis is required for their therapeutic function

SHM Pang, J D'Rozario, S Mendonca, T Bhuvan… - Nature …, 2021 - nature.com
… We previously demonstrated that human MSCs inhibited allergic … a decrease in lung
eosinophils and OVA-specific IL-5 and IL-… , increasing the expression of anti-inflammatory …

Disrupting Tryptophan in the Central Hydrophobic Region selectively mitigates immunomodulatory activities of the Innate Defence Regulator peptide IDR-1002

H Piyadasa, M Hemshekhar, N Osawa… - Journal of Medicinal …, 2021 - ACS Publications
… We also measured the abundance of 28 cytokines using the … by extracellular mediators of
allergic airway inflammation. In fact, … HDM instillations were for 5 consecutive days a week for 2 …

Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash

N Gour, K Sudini, SM Khalil, AM Rule, P Lees… - Environmental …, 2018 - Elsevier
… /Th17 allergic airway response that is not seen after similar … of urban PM that mediate the
potent inflammatory properties … BAL fluid, we observed elevated IL-5 secretion in the lungs of …

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway

HM Ko, SH Choi, W Jee, SH Lee, D Park… - Frontiers in …, 2022 - frontiersin.org
… anesthetized with isoflurane after intranasal instillation. In … The levels of IL-4, IL-5, TNF-α,
and eotaxin were measured using a … the expression of IL-4, IL-5, and eotaxin was highest in the …

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

C Zhang, W Yi, F Li, X Du, H Wang, P Wu, C Peng… - Cell Research, 2018 - nature.com
… an array of cytokines and mediators that act as regulators and … with allergic airway inflammation
and in Cd3δ-Il-5 transgenic … ) or its isotype control by intratracheal instillation (it). CCL-6 …

Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis

M Kawada, H Yokoi, T Kimura, Y Matsumoto… - Allergology …, 2022 - jstage.jst.go.jp
… mucosa to release chemical mediators, such as histamine and … After the nasal instillation of
5 mmol histamine diluted with … -4, IL-5, IL-6, IL-13, mKC and MIP2 were significantly higher in …

Exacerbated lung inflammation in offspring with high maternal antibody levels following secondary RSV exposure

J Ma, T Gong, T Luo, S Li, L Zhong, X Zhao… - Frontiers in …, 2024 - frontiersin.org
… lung via intratracheal instillation of PBS (… IL-5, IL-13, and IFN-γ in lung homogenates were
measured by ELISA. Protein levels of IL-5 and IL-13 were lower, and IFN-γ levels were higher

[HTML][HTML] CpG adjuvant in allergen-specific immunotherapy: finding the sweet spot for the induction of immune tolerance

G Montamat, C Leonard, A Poli, L Klimek… - Frontiers in …, 2021 - frontiersin.org
… activity of main allergic mediators through inhibition of … IL-5, IL-13) and induce B cells to
produce immunoglobulin E (IgE), causing the hallmarks of the allergic disease such as increased

[图书][B] Effect of environmental pollution on asthma due to soybean

D Álvarez-Simón - 2017 - ddd.uab.cat
… , small increases in comparatively low allergen concentrations … increases the risk of IL-5
elevation due to the combined exposure of … Diesel exhaust particles suppress in vivo IFN-gamma