Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells via SIRT1/p66SHC pathway and promotes osteogenesis
H Liu, M Ren, Y Li, R Zhang, N Ma, T Li, W Jiang… - 2021 - researchsquare.com
Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to
explore whether melatonin can promote bone formation and elucidate the mechanisms
underlying this process. In this study, we used an in vitro hydrogen peroxide (H 2 O 2)-
induced oxidative stress model in MC3T3-E1 cells and an in vivo ovariectomized
osteoporotic bone defect model in rats to explore the protective effects of melatonin against …
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to
explore whether melatonin can promote bone formation and elucidate the mechanisms
underlying this process. In this study, we used an in vitro hydrogen peroxide (H 2 O 2)-
induced oxidative stress model in MC3T3-E1 cells and an in vivo ovariectomized
osteoporotic bone defect model in rats to explore the protective effects of melatonin against …
Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1
HD Liu, MX Ren, Y Li, RT Zhang, NF Ma, TL Li… - Free radical …, 2022 - Taylor & Francis
Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to
explore whether melatonin can promote bone formation and elucidate the mechanisms
underlying this process. In this study, we used an in vitro hydrogen peroxide (H2O2)-
induced oxidative stress model in MC3T3-E1 cells and an in vivo ovariectomized
osteoporotic bone defect model in rats to explore the protective effects of melatonin against …
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to
explore whether melatonin can promote bone formation and elucidate the mechanisms
underlying this process. In this study, we used an in vitro hydrogen peroxide (H2O2)-
induced oxidative stress model in MC3T3-E1 cells and an in vivo ovariectomized
osteoporotic bone defect model in rats to explore the protective effects of melatonin against …
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