… We now have strong evidence that the nature of engram cells is quite dynamic. Engram cells
… results are consistent with the notion that mPFC engram cells mature as the memory ages. …

… memory formation, proteins turn over constantly; thus, a protein synthesis-dependent mechanism
is required for the formation of engram memory cells… years after age 65. Several studies …

… -term to long-term memories), and storage (the maintenance of memory in the brain). …
memory formation at a molecular and cellular level by focusing on insights provided using engram …

… forms memory in the brain, and the emerging view is that ensembles of engram cells explain
how memories … for engram cells as a substrate of memory, particularly in rodents; what we …

… Here, we first discuss evidence for the persistence of engram cells and memory-relevant
adaptations in synaptic plasticity, and then propose models of synaptic adaptations and …

… ) in the rodent brain has changed our understanding of how memories are stored and how
… what is known about the effects of forgetting on engram cells and engram cell function. We …

… a, Average dendritic spine density of DG engram cells showed an age-dependent decrease
in 7-month-old APP/PS1 AD mice (n = 7,032 spines) as compared to 5-month-old AD mice (…

… If updating information stored in an engram requires that engram cells have strong synaptic
links, then it cannot be that synaptic efficacy is merely a retrieval mechanism. Synapses …

… have been made in our understanding of the neurobiological substrates of memory – the
so-called memory “engram”. … of the engram is depicted for each stage of memory summarized in …

… Second, we introduce and discuss the concepts of cell assembly and engram cell, the former
has been investigated by psychological experiments and behavioral electrophysiology and …