… The results of the current study suggest that continuous administration of meropenem does
not improve clinically relevant outcomes in critically ill patients with sepsis, including long-…

… the total doses of meropenem used between treatment groups. Since all renal dose adjustments
… , the difference in degree of renal impairment should not have substantially affected our …

… of renal function, a daily dose of 8000 mg of meropenem was required for intermittent … the
largest pharmacokinetic study of meropenem in critically ill patients to date. This sample size …

… meropenem dosing regimens and patient renal function due to its observational nature,
which may have limited the generalisability of the results. However, it reported real-life data, …

… therapy to evaluate illness severity and organ dysfunction. Laboratory parameters included
… for renal function assessment, and tracking total fluid infusion during the first 24 hours of …

… or intermittent hemodialysis), and … renal function marker on meropenem’s clearance was
expected, and was already identified in the scientific literature. Unexpectedly, the renal function …

… administration strategy did not significantly improve PTA in patients with severe renal impairment
… , the current standard intermittent infusion of meropenem dosages are only sufficient to …

… All enrolled patients will receive a loading dose of 1 g of meropenem in both randomization
arms, independently of group assignment or renal function, immediately after clinical …

… It is possible that increasing the dosage to 6 g/day in renal function normal patients can
achieve … [22] observed the pharmacokinetics of meropenem in critically ill patients receiving …

… However, meropenem dosing regimens using … meropenem dosing regimens with Monte
Carlo simulation technique using pharmacokinetic parameters from Asian critically ill patients …