Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy

M Shanaida, R Lysiuk, O Mykhailenko… - Current Medicinal …, 2024 - ingentaconnect.com
… many age-related disorders such as neurodegeneration, metabolic … effect by inhibiting ROS
formation and following neuronal … α-Lipoic acid inhibits the migration and invasion of breast …

The role of biofactors in the prevention and treatment of age‐related diseases

J Frank, K Kisters, OA Stirban, R Obeid… - …, 2021 - Wiley Online Library
… Here, we propose the following definition for the term biofactors: … ), B 6 (pyridoxine respectively
its active form pyridoxal-5′-… In summary, α-lipoic acid is a strong antioxidant and the …

[HTML][HTML] Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal

S Mokhtari, AH Mahdavi, F Jafarpour, MR Andani… - Scientific Reports, 2024 - nature.com
… R-α-lipoic acid (ALA) inhibits protein glycation and AGEs … was assessed after 4.5 days of in
vitro culture (IVC) following the … Researches indicate that pyridoxamine (PM), a form of vitamin …

The antioxidant potential of vitamins and their implication in metabolic abnormalities

P Theodosis-Nobelos, EA Rekka - Nutrients, 2024 - mdpi.com
… that arrive at the site of inflammation after neutrophil influx [14]. … Apart from these effects,
pyridoxine has been shown to act as … α-Lipoic acid (LA) and its reduced form (dihydrolipoic acid) …

[HTML][HTML] (R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro

H Ghelani, V Razmovski-Naumovski… - … and alternative medicine, 2018 - Springer
… fructose produces fructosamine followed by AGEs formation [15, … -induced antioxidant defence
in the reaction mixture after 10, … ALA efficiently inhibited fructose-induced AGEs formation …

[PDF][PDF] Therapeutic agents targeting at AGE-RAGE axis for the treatment of diabetes and cardiovascular disease: a review of clinical evidence

HS Cheng, SH Ton, KA Kadir - Clin Diabetes Res, 2017 - pdfs.semanticscholar.org
… which reported decreased serum AGEs after valsartan therapy in … antioxidant activity, α-lipoic
acid which is a potent antioxidant … potential AGE inhibitors like benfotiamine and pyridoxine […

[HTML][HTML] Attenuation of Glucose-Induced Myoglobin Glycation and the Formation of Advanced Glycation End Products (AGEs) by (R)-α-Lipoic Acid In Vitro

H Ghelani, V Razmovski-Naumovski, RR Pragada… - Biomolecules, 2018 - mdpi.com
… -induced antioxidant defence in the reaction mixture after 10, 20 … system alone or after
co-incubation with α-lipoic acid or … of α-lipoic acid required to inhibit 50% of fluorescent AGEs as …

VITAMIN-LIKE SUBSTANCES

D CANSIZ - A Guide to Vitamins and Their Effects on Diseases, 2023 - books.google.com
… in metabolic reactions, lipoic acid serves as an antioxidant and a … After absorption, it is
immediately cleared from the plasma. … are diminished under pyridoxine deprivation and enhanced …

[HTML][HTML] Beneficial effects of alpha-lipoic acid on hypertension, visceral obesity, UCP-1 expression and oxidative stress in zucker diabetic fatty rats

A El Midaoui, IG Fantus, A Ait Boughrous, R Couture - Antioxidants, 2019 - mdpi.com
… of metabolic syndrome. This study aims to investigate whether α-lipoic acid (LA), a potent
antioxidant, … After dietary assimilation, LA is transported into cells and reduced to dihydrolipoic …

Neuroprotective effects of the advanced glycation end-product inhibitors LR90 and pyridoxamine in experimental diabetes.

HE Brooke - MATRIX METALLOPROTEINASES AND …, 2019 - search.proquest.com
… aldose reductase inhibitors (ARIs) which prevent polyol flux; antioxidants such as α-lipoic
acid; … been previous studied using anti-oxidant therapies (α-lipoic acid) following STZ-induced …