Protective effects of melatonin on methamphetamine-induced bloodbrain barrier dysfunction in rat model

J Namyen, K Permpoonputtana, C Nopparat… - Neurotoxicity …, 2020 - Springer
… The results showed a significantly increased hippocampal expression of albumin (P < 0.05;
Fig. 1(m)) induced by METH as compared to control groups. This effect could be protected by …

Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown

J Gonçalves, RA Leitão, A Higuera-Matas… - Brain, behavior, and …, 2017 - Elsevier
… Specifically, there was an increase of BBB permeability due to alterations … brain regions
analyzed, we concluded that METH abuse leads to hippocampal and striatal barrier permeability

Peripheral ammonia and blood brain barrier structure and function after methamphetamine

NA Northrop, LE Halpin, BK Yamamoto - Neuropharmacology, 2016 - Elsevier
Methamphetamine (Meth) is a widely abused psychostimulant known to damage brain
Similar effects were observed in various regions of the cortex as well as the hippocampus

[HTML][HTML] Endoplasmic reticulum stress mediates methamphetamine-induced bloodbrain barrier damage

X Qie, D Wen, H Guo, G Xu, S Liu, Q Shen… - Frontiers in …, 2017 - frontiersin.org
Methamphetamine (METH) abuse causes serious health problems worldwide, and long-term
use of METH disrupts the bloodbrain barrier (BBB). Herein, we explored the potential …

Methamphetamine and the BloodBrain Barrier

RA Leitão, V Coelho-Santos, AP Silva - Neuropathology of drug addictions …, 2016 - Elsevier
… overlooked, we showed that METH (30 mg/kg, ip) increased BBB permeability in the mice
hippocampus together with an increase of MMP-9 activity and immunoreactivity (Martins et al., …

[HTML][HTML] Overview of blood-brain barrier dysfunction in methamphetamine abuse

L Pang, Y Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
… This study demonstrated that chronic METH increased α-syn expression in mice hippocampal
neurons [68]. The α-syn produced by neurons were spread to astrocytes and gradually …

[HTML][HTML] Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse

Y Bai, Y Zhang, J Hua, X Yang, X Zhang, M Duan… - Scientific reports, 2016 - nature.com
… TJP expression induced by methamphetamine in the cortex (d) and hippocampus (e), as …
Methamphetamine treatment transiently increased the phosphorylation of ERK, JNK and …

[HTML][HTML] The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties

TP Buzhdygan, CR Rodrigues, HM McGary… - Journal of …, 2021 - Springer
Methamphetamine, which closely resembles chemical structure and pharmacological …
Here, we report that extracellular PECAM-1 was transiently increased in hBMVEC at 2 h after …

Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro

S Patel, CR Leibrand, P Palasuberniam… - Antimicrobial agents …, 2017 - Am Soc Microbiol
… [of body weight]) methamphetamine exposure in mice, barrier permeability to the paracellular
compound Evans blue was altered, albeit transiently, with increases observed at 24 h but …

Impact of Methamphetamine on Blood-Brain Barrier: Role of Exercice

VCA Pinheiro - 2016 - search.proquest.com
… Since our results suggest an increase of the BBB permeability in the hippocampus, it may
present an opportunity to enhance delivery of chemotherapeutic agents to the underlying …