… SAR, for Structure-Activity-Relationships. In the early days of … methylation and the two work
in concert: Histone methylation … that lead to neurofibrillary tangles and the pathological effects …

… axons which forms intracellular neurofibrillary tangles (NFTs) [1]. … effect of methylation on
Tau phosphorylation, methylation may … to be in inverse relation to the extent of methylation [24]. …

… phosphorylation of tau protein Its association with NFTs is more apparent in the initial disease
stage Promoter methylation … a more causal relationship between DNA methylation and the …

… A crosstalk between methylation and phosphorylation has … p53 lysine methylation was mostly
studied in relation to rapidly … the presence of intracellular neurofibrillary tangles (NFTs) of …

… to the markers of neurofibrillary tangles in neurons of patients … The relationship between DNA
methylation, pathogenesis … been correlated with eIF4E phosphorylation in both human and …

… a phosphorylated or acetylated residue (% of total methylated … possible temporal relationship
regulating the activity of PLK1. … Neurofibrillary tangles are caused by the agglomeration of …

… activity is in relation with the change in structure of the protein, which in turn depends on the
extent of phosphorylation. As reported from … /hyperphosphorylation of neurofibrillary tangles. …

… tangle (NFT) formation due to abnormal or excessive tau … Genetic studies have revealed
a relationship between the structural … regulation of methylation levels of tau phosphorylation-…

… in AD neurons with neurofibrillary tangles 46 . … catalytic subunit of PP2A is phosphorylated
at the C-terminus … a conserved regulatory relationship between C-terminal methylation and …

… methylation in neurodegenerative diseases, and explore the links between recently identified
non-histone methylated … Much like phosphorylation, it appears that methylation is also …