Microbe-derived uremic solutes enhance thrombosis potential in the host
ABSTRACT p-Cresol sulfate (p CS) and indoxyl sulfate (IS), gut microbiome-derived
metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the
setting of impaired kidney function. While pharmacologic provision of p CS or IS can
promote pro-thrombotic phenotypes, neither the microbial enzymes involved nor direct gut
microbial production have been linked to CVD. Untargeted metabolomics was performed on
a discovery cohort (n= 1,149) with relatively preserved kidney function, followed by stable …
metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the
setting of impaired kidney function. While pharmacologic provision of p CS or IS can
promote pro-thrombotic phenotypes, neither the microbial enzymes involved nor direct gut
microbial production have been linked to CVD. Untargeted metabolomics was performed on
a discovery cohort (n= 1,149) with relatively preserved kidney function, followed by stable …
[PDF][PDF] Microbe-derived uremic solutes enhance thrombosis potential in the host
W Tang, MA Fischbach, SL Hazen - 2023 - authors.library.caltech.edu
ABSTRACT p-Cresol sulfate (pCS) and indoxyl sulfate (IS), gut microbiome-derived
metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the
setting of impaired kidney function. While pharmacologic provision of pCS or IS can promote
pro-thrombotic phenotypes, neither the microbial enzymes involved nor direct gut microbial
production have been linked to CVD. Untargeted metabolomics was performed on a
discovery cohort (n= 1,149) with relatively preserved kidney function, followed by stable …
metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the
setting of impaired kidney function. While pharmacologic provision of pCS or IS can promote
pro-thrombotic phenotypes, neither the microbial enzymes involved nor direct gut microbial
production have been linked to CVD. Untargeted metabolomics was performed on a
discovery cohort (n= 1,149) with relatively preserved kidney function, followed by stable …
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