… is sufficient to induce a Notch response in receiver cells. Together, these studies define the
functional elements of an E3 ligase needed for ligands to induce a Notch signaling response. …

… We identified the E3 ubiquitin ligase, Mib1, which promotes Notch signaling, as a regulator
… Mutations in mib1 and ubiquitous expression of Mib1 that lacks its ubiquitin ligase activity …

… the effect of Mind bomb 2 (MIB2), an E3 ligase on Notch1 … form of Notch (NICD) is targeted
by several ubiquitin ligases. … Notch activity, further supporting the function of RNF8 as the …

… Here we show that Mind bomb-2 (MIB2)-mediated Lys-63-linked ubiquitination of the GABA
… We identified MIB2 as the E3 ligase triggering Lys-63-linked ubiquitination and lysosomal …

… Here we show that Mind bomb-2 … Upon overexpression of those E3 ligases in neurons we
found that the E3 ligase … is the ubiquitination and internalization of Notch ligands (31). Because …

… Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates TNF-induced
apoptosis through ubiquitylation of receptor-interacting protein kinase 1 (RIPK1) and …

… Mind bomb 2 is an E3 ligase involved in the regulator of cytoskeletal proteins (manuscript
in preparation) • Delivered 3 oral and 14 poster presentations at national and international …

… While investigating Drosophila oogenesis, we found that the putative E3 ubiquitin ligase,
Mind bomb 2 (Mib2), is required to promote epithelial stability and the collective cell migration …

… We identify the E3 ubiquitin ligase Mind Bomb-2 (MIB2) as a FAT1-interacting protein …
and its associated E3 ligase MIB2, which is essential for YAP/TAZ-dependent angiogenesis. …

… separable from its function in Notch signaling. Our work thereby identifies a novel function
of this E3 ubiquitin ligase and establishes Mib1 as an essential regulator of the PCP pathway. …