Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available
antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. …

… is not entirely understood, we herein investigated the role of immune activation in HD using
the R6/2 transgenic (Tg) HD model … However, some studies have reported that minocycline …

… minocycline have also been described in PD animal models, … of doxycycline for several
neurodegenerative diseases was … the ability of minocycline, doxycycline, and the non-antibiotic …

… Like doxycycline, minocycline seems to be partly metabolized … involved in their formation
have not been determined in man (… in a transgenic mouse model of Huntington disease. Nature …

… tested drug to demonstrate its beneficial or detrimental effects. … , we did not observe a
breakthrough effect of minocycline in any … model of VF CA, minocycline did not confer benefits on …

… beneficial effects of TC derivatives (particularly doxycycline and minocycline) on amyloidogenic
disorders… The two structural models of Aβ fibrils in this study were generated starting from …

… with subantimicrobial doses of doxycycline and minocycline, in … trial; UHDRS, unified
Huntington's disease rating scale; … pars compacta of a rat model of Parkinson's disease. Note the …

… , a comprehensive investigation on the effects of minocycline treatment on human glial cells
is … effects of minocycline at different concentrations in glial cells using an in vitro model. To …

… In a Drosophila model of Aβ toxicity, doxycycline prevents Aβ … such huntingtin in Huntington
disease mice model [181]. … , we should not forget that a suitable minocycline doses must …

… of minocycline in Japan suggested that this drug is useful for … In a randomized study, longterm
treatment with doxycycline, … model of Huntington disease. Nat Med 6: 797-801, 2000. 45. …