[HTML][HTML] Oligomeropathies, inflammation and prion protein binding

G Forloni, P La Vitola, C Balducci - Frontiers in Neuroscience, 2022 - frontiersin.org
… effect of minocycline against the toxic effects of ICV AβOs in mice. … doxycycline showed
double protective activity – anti-amyloidogenic and anti-inflammatory – in experimental models

[HTML][HTML] … risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

RL Openshaw, DM Thomson, JM Penninger… - …, 2017 - Springer
… Overall, Map2k7 haploinsufficiency causes a distinctive pattern of cognitive impairment …
populations and highlights the possibility of treating some of these deficits with minocycline. …

New views on an old antibiotic: Effects of minocycline on innate versus stress-induced behavioural, immunological, and microbiome changes

AK Schmidtner - 2019 - epub.uni-regensburg.de
… two different animal models for psychiatric disorders, selective … beneficial effects of minocycline.
First, the influence of … second-generation doxycycline and minocycline were identified. …

[HTML][HTML] Pediatric use of tetracyclines: focus on neurodevelopmental effects

I Inta, GF Hoffmann, M Bettendorf - Pediatric Research, 2017 - nature.com
… Therefore we aimed to test whether minocycline protects also … model is based on the inhibitory
effect of minocycline on … Therefore, its inhibition by minocycline or doxycycline may also …

Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial

GB Gunn, TR Mendoza, AS Garden, XS Wang… - Supportive Care in …, 2020 - Springer
… well as in rheumatoid arthritis [9] and Huntington disease [13]. Minocycline has been used
as a … In piecewise linear mixed–effects models, the minocycline and placebo groups differed …

[PDF][PDF] Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

… of doxycycline in models of cerebral ischemia, spinal cord injury, PD, Huntington’s disease,
… Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis. …

[HTML][HTML] Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

A Asadi, M Abdi, E Kouhsari, P Panahi… - Journal of global …, 2020 - Elsevier
… Human and animal model studies have demonstrated that … be susceptible to doxycycline,
minocycline or both according to … role of minocycline in patients with Huntington disease (HD), …

[HTML][HTML] Tetracycline and viruses: a possible treatment for COVID-19?

JA Mosquera-Sulbaran, H Hernández-Fonseca - Archives of virology, 2021 - Springer
… and AIF in cell culture and in a mouse model of Huntington's disease [31]. In this regard, the
… Tetracyclines (eg, tetracycline, halogenated tetracyclines, doxycycline, and minocycline) are …

Combining hydroxychloroquine and minocycline: potential role in moderate to severe COVID-19 infection

SS Gautam, CS Gautam, VK Garg… - Expert Review of Clinical …, 2020 - Taylor & Francis
… VeroE6 cells but no effect was observed in reconstituted human airway epithelium model. In
… In this study, doxycycline along with HCQ led to improve clinical outcome of high-risk COVID…

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

CM Sellgren, J Gracias, B Watmuff, JD Biag… - Nature …, 2019 - nature.com
not fully explain the observed increase in synapse uptake. Finally, we demonstrate that the
antibiotic minocycline … who did or did not receive minocycline or doxycycline for at least 90 d …