[HTML][HTML] Minocycline effects on IL-6 concentration in macrophage and microglial cells in a rat model of neuropathic pain
… Pro-inflammatory cytokines are responsible for the early … minocycline 10, 20, and 40 mg/kg
attenuated the production … role in reducing the factors contributing to pain facilitation[24]. …
attenuated the production … role in reducing the factors contributing to pain facilitation[24]. …
Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat
D Amorim, S Puga, R Braganca, A Braga… - Behavioural brain …, 2017 - Elsevier
… data from animal models suggested that minocycline, a semi-… attenuated pain behaviour
evoked by innocuous mechanical … facilitation are differentially sensitive to minocycline. …
evoked by innocuous mechanical … facilitation are differentially sensitive to minocycline. …
Pain-relieving effectiveness of co-treatment with local tramadol and systemic minocycline in carrageenan-induced inflammatory pain model
… cytokine levels of paw and spinal cord tissues in a rat model of … , our results suggest that
pro-inflammatory cytokines TNF-α … Inhibition of microglial activation attenuates the development …
pro-inflammatory cytokines TNF-α … Inhibition of microglial activation attenuates the development …
Systemic lipopolysaccharide-induced pain sensitivity and spinal inflammation were reduced by minocycline in neonatal rats
… (LPS) produced hyperalgesia (pain facilitation), which is possibly … Minocycline attenuated
an LPS-induced increase in the … level and in the central nervous system in our animal model. …
an LPS-induced increase in the … level and in the central nervous system in our animal model. …
[HTML][HTML] Paradoxical effect of minocycline on established neuropathic pain in rat
… hairs for mechanical allodynia were used to evaluate pain behavior. Thermal hyperalgesia
and mechanical allodynia were attenuated … of minocycline before nerve injury attenuated pain …
and mechanical allodynia were attenuated … of minocycline before nerve injury attenuated pain …
Participation of pro-and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain
M Zychowska, E Rojewska, W Makuch… - European journal of …, 2016 - Elsevier
… administration of minocycline attenuates hypersensitivity in various models of neuropathy …
activation and, therefore, reduced expression of proinflammatory cytokines (Ledeboer et al., …
activation and, therefore, reduced expression of proinflammatory cytokines (Ledeboer et al., …
… microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain
Z Li, H Wei, S Piirainen, Z Chen, E Kalso… - Brain, behavior, and …, 2016 - Elsevier
… mechanical allodynia regularly in this period (Fig. 5A). Interestingly, minocycline attenuated
mechanical allodynia … afterward, with the anti-allodynic effect being most prominent before …
mechanical allodynia … afterward, with the anti-allodynic effect being most prominent before …
Minocycline as a promising therapeutic strategy for chronic pain
YQ Zhou, DQ Liu, SP Chen, J Sun, XM Wang… - Pharmacological …, 2018 - Elsevier
… component of descending nociceptive facilitation circuitry [40]. … significantly attenuate the
mechanical allodynia in a rat model … stimuli such as pro-inflammatory cytokines, heat shock and …
mechanical allodynia in a rat model … stimuli such as pro-inflammatory cytokines, heat shock and …
Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes
Z Song, B Xiong, X Guan, F Cao, A Manyande… - Acta Pharmacologica …, 2016 - nature.com
… in the expression of pro-inflammatory cytokines and chemokines. … of NF-κB in BCP rat
models induced by inoculating Walker 256 … , and its potential role is facilitating pain perception. …
models induced by inoculating Walker 256 … , and its potential role is facilitating pain perception. …
Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis
B Liu, M Su, SJ Tang, X Zhou, H Zhan, F Yang… - … pain, 2016 - journals.sagepub.com
… mediators such as proinflammatory cytokines that facilitate … inhibitor minocycline attenuated
mechanical allodynia. The … the cystitis-induced pain through facilitating NR phosphorylation. …
mechanical allodynia. The … the cystitis-induced pain through facilitating NR phosphorylation. …