Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model
E Rojewska, A Piotrowska, W Makuch, B Przewlocka… - …, 2016 - Elsevier
… it administration of minocycline: minocycline attenuated the … -8048 significantly attenuated
mechanical allodynia from 14.2 … of JM6 attenuated mechanical allodynia from 14.2 ± 1.0 g to …
mechanical allodynia from 14.2 … of JM6 attenuated mechanical allodynia from 14.2 ± 1.0 g to …
[PDF][PDF] Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
… In a rat model of bone cancer pain induced by inoculation of … with minocycline not only
alleviated mechanical allodynia, but … Spinal treatment of LXA4 attenuated neuropathic pain and …
alleviated mechanical allodynia, but … Spinal treatment of LXA4 attenuated neuropathic pain and …
Experimental drugs for neuropathic pain
K Salat, B Gryzlo, K Kulig - Current Neuropharmacology, 2018 - ingentaconnect.com
… to pain signal facilitation and increased pain sensitivity [22]. … NP in both animal models
and clinical studies. Several … effects of minocycline which attenuated allodynia, hyperalgesia, …
and clinical studies. Several … effects of minocycline which attenuated allodynia, hyperalgesia, …
Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models
Q Huang, XF Mao, HY Wu, TF Li, ML Sun, H Liu… - Journal of …, 2016 - Springer
… inhibited by the microglial inhibitor minocycline. In contrast, … attenuates pain hypersensitivity,
regardless of the pain … synaptic transmission, contributing to pain facilitation [15]. Li et al. …
regardless of the pain … synaptic transmission, contributing to pain facilitation [15]. Li et al. …
Effect of Electroacupuncture at Fengchi on Facial Allodynia, Microglial Activation, and Microglia–Neuron Interaction in a Rat Model of Migraine
P Pei, S Cui, S Zhang, S Hu, L Wang, W Yang - Brain sciences, 2022 - mdpi.com
… -1, proinflammatory cytokines, and cytokine receptors in the … attenuated in the SA group
(model & SA: p > 0.05 for both). … -like effect of minocycline on microglia activation in migraine rat. …
(model & SA: p > 0.05 for both). … -like effect of minocycline on microglia activation in migraine rat. …
Neuroimmune mechanisms of pain: basic science and potential therapeutic modulators
JSY Lim, PCA Kam - Anaesthesia and Intensive Care, 2020 - journals.sagepub.com
… glial inhibitor, inhibits mechanical allodynia in animal models. … Minocycline suppressed
glial priming in an animal study … , and attenuates neuropathic pain in a rat model. However, a …
glial priming in an animal study … , and attenuates neuropathic pain in a rat model. However, a …
β-Caryophyllene, a CB2-receptor-selective phytocannabinoid, suppresses mechanical allodynia in a mouse model of antiretroviral-induced neuropathic pain
… in animal models of paclitaxel-induced neuropathic pain and … , BCP attenuated the ddC-established
mechanical allodynia. … minocycline, which inhibits inflammatory cytokine production …
mechanical allodynia. … minocycline, which inhibits inflammatory cytokine production …
[HTML][HTML] … 2, 3-dioxygenase-2 and kynurenine 3-monooxygenase, enzymes of the kynurenine pathway, significantly diminishes neuropathic pain in a rat model
E Rojewska, K Ciapała, A Piotrowska… - Frontiers in …, 2018 - frontiersin.org
… administration of minocycline, a microglia/macrophage inhibitor, not only attenuated tactile
and … via the administration of minocycline influences neuropathic pain-related behaviors and …
and … via the administration of minocycline influences neuropathic pain-related behaviors and …
Minocycline for controlling neuropathic pain: a systematic narrative review of studies in humans
… 14 Several animal studies have shown that minocycline attenuates neuropathic pain after …
microglia, thereby reducing the production of pro-inflammatory cytokines. Citation11 – Citation…
microglia, thereby reducing the production of pro-inflammatory cytokines. Citation11 – Citation…
Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics
K Ciapała, J Mika - Pharmaceuticals, 2023 - mdpi.com
… In summary, minocycline restores the neuroimmunological balance that is biased toward …
In animal models of neuropathic pain, NRF2 activation has been shown to attenuate …
In animal models of neuropathic pain, NRF2 activation has been shown to attenuate …