Renal revascularization attenuates myocardial mitochondrial damage and improves diastolic function in pigs with metabolic syndrome and renovascular hypertension
RA Farahani, S Yu, CM Ferguson, XY Zhu… - Journal of …, 2022 - Springer
… restoration of kidney function by PTRA ameliorates myocardial mitochondrial damage and
preserves cardiac function … mitochondrial protection by PTRA preserves cardiac structure and …
preserves cardiac function … mitochondrial protection by PTRA preserves cardiac structure and …
[HTML][HTML] Mitochondrial protection partly mitigates kidney cellular senescence in swine atherosclerotic renal artery stenosis
… (ARAS) remains the leading cause of renovascular hypertension… The mitochondrial-targeted
peptide elamipretide restores … In summary, mitochondrial protection improved renal function …
peptide elamipretide restores … In summary, mitochondrial protection improved renal function …
Renovascular disease induces mitochondrial damage in swine scattered tubular cells
AA Nargesi, XY Zhu, SM Conley… - … Physiology-Renal …, 2019 - journals.physiology.org
… In atherosclerotic RVD, the kidney is often affected by both … , mitoprotection restored
mitochondrial structure and function … did not aggravate stenotic kidney dysfunction in the short time …
mitochondrial structure and function … did not aggravate stenotic kidney dysfunction in the short time …
Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension
A Eirin, B Ebrahimi, SH Kwon, JA Fiala… - Journal of the …, 2016 - Am Heart Assoc
… To simulate concurrent atherosclerosis, HC‐RVH pigs started a high‐cholesterol diet (2% …
Despite unchanged blood pressure, mitochondrial protection restores cardiolipin levels, …
Despite unchanged blood pressure, mitochondrial protection restores cardiolipin levels, …
The metabolic syndrome induces early changes in the swine renal medullary mitochondria
A Eirin, JR Woollard, CM Ferguson, KL Jordan… - Translational …, 2017 - Elsevier
… the mitochondrial permeability transition pore (mPTP). We have previously shown that treatment
with ELAM restores renal function in swine renovascular disease.… to protect the kidney in …
with ELAM restores renal function in swine renovascular disease.… to protect the kidney in …
Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome
AA Nargesi, MC Farah, XY Zhu, L Zhang… - … of hypertension, 2021 - academic.oup.com
… cause of secondary hypertension and renal failure commonly … this sex-specific protection.
Our observations demonstrate … in Lean + RVH failed to restore membrane potential, it resulted …
Our observations demonstrate … in Lean + RVH failed to restore membrane potential, it resulted …
Experimental renovascular disease induces endothelial cell mitochondrial damage and impairs endothelium-dependent relaxation of renal artery segments
AA Nargesi, XY Zhu, IM Saadiq… - … of hypertension, 2020 - academic.oup.com
… of swine renovascular disease (RVD) induce mitochondrial … secondary hypertension and
renal dysfunction characterized … Atherosclerotic RVD is prevalent in the elderly population …
renal dysfunction characterized … Atherosclerotic RVD is prevalent in the elderly population …
Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs
AA Nargesi, L Zhang, H Tang, KL Jordan… - … of hypertension, 2019 - journals.lww.com
… Renovascular disease (RVD) accounts for an important … and RAS on the kidney outweigh
sex-specific protection [16,17] … that mitochondrial damage precedes loss of renal function in …
sex-specific protection [16,17] … that mitochondrial damage precedes loss of renal function in …
Phase 2a clinical trial of mitochondrial protection (elamipretide) during stent revascularization in patients with atherosclerotic renal artery stenosis
… kidney functional outcomes of revascularization in patients with ARAS. Renal stenting alone
often fails to restore kidney function in … Our experimental studies in swine models of RAS …
often fails to restore kidney function in … Our experimental studies in swine models of RAS …
Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndrome
F Yuan, AF Hedayat, CM Ferguson… - American Journal …, 2018 - journals.physiology.org
… EC mitochondria and attenuate coronary vascular injury and … in MetS pigs compared with
lean pigs but was restored to … shown in pigs with renovascular hypertension that treatment …
lean pigs but was restored to … shown in pigs with renovascular hypertension that treatment …