… -β (Aβ) peptides, while NFTs are intracellular inclusions rich in … identify cellular phenotypes
associated with a disease state … modeled in iPSC-derived glutamatergic neurons, revealing a …

… intracellular level, eg endocytic dysfunction, which may inform the design of promising in vitro
models… Aβ domain), phenotypic analysis of iPSC-derived iN cells revealed Aβ anomalies …

… However, this work also revealed that these changes are not … Other AD-related phenotypes
such as ER stress [3] and … intracellular AβO accumulation with associated ER and oxidative …

… In this study, increased extracellular levels of Aβ(1–42) were … cell (iPSC)-derived cell models
for sporadic Alzheimer’s disease (… Certain phenotypes associated with sAD might not be …

… of extracellular β-amyloid plaques, intracellular neurofibrillary … -year-old SAD patient
revealed significant gene expression … of factors associated with the disease phenotypes and the …

… of the disease include the formation of extracellular amyloid … vast majority of AD cases,
revealed that factors such as glial cell … methods effectively achieve the AD phenotype in vitro, they …

… the strength of iPSC-derived models for brain diseases. … The neuropathology of AD includes
extracellular deposits of … between DE9 mutation and AD phenotype, we also generated gene…

… phenotypes observed in AD patients, iPSC-based modeling … /Aβ40 ratio and enhanced
intracellular free calcium level upon … broad range of ages revealed that iNs, but not iPSC-derived …

… advanced models for preclinical investigations. These … At first, we measured the amount of
extra- and intracellular Ab40 … analysis revealed that these proteins were associated with bio…

… modelling. This review covers an overview of iPSCs and a summary of the AD-relevant
phenotypes of … In some iPSC-derived sAD neurons, the extracellular Aβ40 and Aβ42 levels are …