… phenotypes observed in AD patients, iPSC-based modeling … /Aβ40 ratio and enhanced
intracellular free calcium level upon … broad range of ages revealed that iNs, but not iPSC-derived …

… iPSC-neuron models have been widely employed to model AD … This self-organising phenotype
gives 3D suspension … show intracellular Aβ accumulation, ER and oxidative stress were …

… modified animal models and the phenotypes of iPSC-derived … Pathological features of AD
include extracellular deposition … of human AD brains revealed a tau homeostasis signature in …

… of Aβ and tau, oxidative stress and mitochondrial dysfunction, … intracellularly[104] and that
the tau aggregation phenotype … reveal novel therapeutic targets for this devastating disease[…

… challenges to be addressed and areas of further research for iPSC modeling of AD. … Modeling
Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ …

… -iPSCs demonstrated aberrant accumulation of intracellular … AD-iPSC model that recapitulated
the crucial phenotypes of AD … of GSK3β has been revealed in iPSC-derived neurons from …

… consist in extracellular dense amyloid plaques composed of β amyloid (Aβ); and intracellular
… Each panel shows the B allele frequency (BAF) and the log R ratio (LRR). BAF at values …

… Using this approach, we demonstrated that the extracellular … model of this AD patient would
better reveal the pathogenic … very similar AD-related phenotypes, including increased levels …

… between intracellular Aβ42:40 from the cell lysate of iPSC … can induce ER stress and
oxidative stress phenotypes [91], … Tau phosphorylation has also been well studied and shows …

… brain samples and animal models. However, these … SAD line showed higher ROS levels and
intracellular Aβ. … , which captures an early phenotype of the disease, raises further questions…