Logical modeling and dynamical analysis of cellular networks

W Abou-Jaoudé, P Traynard, PT Monteiro… - Frontiers in …, 2016 - frontiersin.org
… framework with advanced methods and tools to analyze behavioral properties (… models
(Section 4). Finally, we illustrate these assets on T cell signaling and cell cycle control networks (…

Computational modeling of signal transduction networks without kinetic parameters: Petri net approaches

I Koch, B Büttner - American Journal of Physiology-Cell …, 2023 - journals.physiology.org
signaling pathways and basic modeling techniques. Then, we introduce Petri nets and explain
analysis and simulation techniques that are, … tational model of intracellular signaling and …

Mathematical and statistical techniques for systems medicine: the Wnt signaling pathway as a case study

AL MacLean, HA Harrington, MPH Stumpf, HM Byrne - Systems Medicine, 2016 - Springer
… transduction pathways: multistep sequences of intracellular signaling events … modeling
approaches is not exhaustive: in limited space, we make no mention of Boolean, semi-quantitative

A network-based approach for semi-quantitative knowledge mining and its application to yield variability

B Schauberger, S Rolinski… - Environmental Research …, 2016 - iopscience.iop.org
… for improving crop models with respect to YV. As expected, our method confirms that current
modeling approaches have … Thus our approach can be seen as a cross-validation of existing …

Deciphering epithelial–mesenchymal transition regulatory networks in cancer through computational approaches

GA Burger, EHJ Danen, JB Beltman - Frontiers in oncology, 2017 - frontiersin.org
modeling approaches and point out outstanding questions in which computational modeling
… Here, we review such modeling approaches on (partial) EMT and how they have helped to …

Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis

LK Amstein, J Ackermann, J Hannig… - PLoS Computational …, 2022 - journals.plos.org
… , and necroptosis in cellular signaling pathways initiated by … modeling approaches, such as,
eg, an ODE-based model of the NF-… Here, we developed a semi-quantitative PN model and …

From the mechanistic modeling of signaling pathways in cancer to the interpretation of models and their contributions: clinical applications and statistical evaluation

J Béal - 2020 - theses.hal.science
… The purpose of this section is to present in a schematic, and therefore somewhat caricatural,
manner the two competing formal modeling approaches that will be used in this thesis and …

Improving safety in complex systems: A review of integration of functional resonance analysis method with semiquantitative and quantitative approaches

A Kumar, R Upadhyay, B Samanta… - Human Factors and …, 2024 - Wiley Online Library
… to analyze complex socio‐technical systems to improve safety levels. This review article …
of current literature focused on semiquantitative and quantitative methods employed for quanti…

Qualitative Methods for Modeling Biochemical Systems and Datasets: The Logicome and the Reaction Systems Approaches

C Panchal - 2018 - doria.fi
… Also, the qualitative modeling approachesanalysis of cellular signaling or regulatory
networks (see for example [63, 89]). The study in [93] introduced scalable qualitative approach for …

A scalable method for parameter-free simulation and validation of mechanistic cellular signal transduction network models

J Romers, S Thieme, U Münzner… - NPJ systems biology and …, 2020 - nature.com
modelling—is limited to qualitative or semi-quantitative simulation methods at the genome
scale. … -free model creation and simulation method for models of signal transduction. Unique …