Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
… In acute PTZ exposure however, galanin modulated seizures significantly. While we
hypothesized to see antiepileptic effects upon modulation of galanin, our observations did not …

Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy

JS Medel-Matus, D Shin, R Sankar, A Mazarati - Experimental neurology, 2017 - Elsevier
… confirm that galanin is a tangible modulator of … galanin on GalR1 improves epilepsy-associated
monoamine perturbations and related comorbidities suggests that endogenous galanin, …

Epilepsy-associated alterations in hippocampal excitability

M Navidhamidi, M Ghasemi… - Reviews in the …, 2017 - degruyter.com
… The mGluRs are G protein-coupled receptors involved in the modulation of neuronal
excitability and glutamatergic transmission via regulation of membrane ion channel activity and …

[HTML][HTML] Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin

F Gimeno-Ferrer, A Eitner, R Bauer… - Experimental …, 2023 - Elsevier
… Pathological increases in brain cortical excitability play an important role in human central
nervous diseases ranging from epilepsy to migrainic headache. Excitability of nerve cells is …

[HTML][HTML] Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice

R Collard, MC Aziz, K Rapp, C Cutshall… - Frontiers in Neural …, 2022 - frontiersin.org
… The amygdala is enriched in neuropeptides that modulate neuronal activity and can be …
seizures and downstream breathing control following seizures, and the depletion of galanin may …

Neuropeptides: A promising target for treating seizures

N Menon, KS Prabhavalkar, LK Bhatt - Neuropeptides, 2017 - Elsevier
… characteristics of galanin receptors suggests its participation in the modulation of … of the
hippocampal excitability. SST is known to exhibit antiseizure actions in the hippocampus region …

Increased expression of galanin and its receptors in the dorsal hippocampus during epileptogenesis in a rat model of pilocarpine-induced temporal lobe epilepsy

J Sun, S Xu, X Li, T Li, C Liu, J Zhou, G Luan, Z Xu - Stress and Brain, 2023 - sciopen.com
… Meanwhile, galanin-positive cells appeared, while galanin-… in galanin synthesis and release
during the acute seizure phase… when attempting to pharmacologically modulate this system. …

The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory-and inhibitory neurotransmission

AB Walls, SP Flynn, PJ West, MS Müller, LK Bak… - Epilepsy Research, 2016 - Elsevier
… Our data support the hypothesis that NAX-5055 limits hippocampal excitability through
presynaptic mechanisms and also expands this hypothesis by suggesting that NAX-5055 could …

Galanin Analogs Prevent Seizure-Induced Respiratory Arrest

R Collard, MC Aziz, K Rapp, C Cutshall, E Duyvesteyn… - bioRxiv, 2022 - biorxiv.org
… The amygdala is enriched in neuropeptides that modulate neuronal activity and … seizure
burden. Therefore, the purpose of this study is to use rodent models to demonstrate how galanin

Neuroanatomical localization of galanin in zebrafish telencephalon and anticonvulsant effect of galanin overexpression

P Podlasz, A Jakimiuk, N Kasica-Jarosz… - ACS chemical …, 2018 - ACS Publications
… Several studies have shown that galanin is involved in seizure regulation and can modulate
epileptic activity in the brain. The overall goal of the study was to establish zebrafish as a …