… In this Review, we discuss aspects of the circadian clock in Drosophila melanogaster and
mammals, including the components of these molecular oscillators, the function and …

… Summary The mammalian circadian clock is built on a feedback loop in which PER and CRY
proteins repress their own transcription. We found that in mouse liver nuclei all three PERs, …

… rhythms are driven by an intrinsic machinery called the circadian clock, which generates
self-sustaining rhythms … mechanisms of the mammalian circadian clock at the molecular, cellular…

… The mammalian circadian system is composed of a central clock situated in the hypothalamic
suprachiasmatic nucleus (SCN) and peripheral clocks of each tissue and organ in the body…

… as the genomic targets of CLOCK and BMAL1 using ChIP-seq methods. We describe the
dynamics of the core circadian clock transcriptional system. CLOCK and BMAL1 interact with …

… circadian rhythm development during ontogeny in mammals … on the molecular mechanisms
that suppress circadian molecular … the biological implications of repressing cellular circadian …

… Simple Summary In mammals, circadian rhythms in nearly all behaviors and physiological
processes are controlled by the suprachiasmatic nucleus, a collection of neurons in the …

… the circadian clock in mammals has been informed by progress on two fronts: first, by the
biochemical definition of components of circadian … of key domains of clock proteins (Box 1). This …

… 7, we present a model of the mammalian circadian clock that incorporates both blocking-type
and displacement-type mechanisms. At CT4–8 (“active phase”), the CLOCK–BMAL1 …

… about how aging affects the circadian clock, how the functional decline of the circadian …
knowledge about the molecular connections between the mammalian circadian clock and aging, …