… microsatellite unstable (MSI) tumors (23%), (ii) microsatellite … reported to act as a tumor
suppressor and to be dysregulated … are benign neoplasms of the upper third of the stomach …

… gastric glands by intestinal metaplasia over the entire stomach, but … Microsatellite instability
has been detected in intestinal … The tumor suppressor gene TP53 is mutated at a high rate in …

… mutations in the tumor suppressor gene CDH1, although … in preneoplastic and neoplastic
lesions of the stomach, with … parameters, microsatellite status, and frequency of TP53 mutations …

… small bowel and stomach are separately mentioned in this chapter. … The MMR proteins and
microsatellite genes can be variably lost … of the tumor suppressor gene APC. The name of the …

… of selected genetic (TP53 mutations and microsatellite … the lower esophagus is replaced by
specialized columnar intestinal … As for other solid cancer types, the TP53 tumor suppressor is …

… that numerous tumor suppressor genes exhibit aberrant … from normal esophageal lining, to
specialized intestinal metaplasia, … as the p53 positivity rate in Barrett’s esophagus dysplasia is …

… of a number of tumor suppressor genes, cell cycle regulators, … frame p14 ARF lesions (LOH
at microsatellite D9S925, … pathway is responsible for promoting the intestinal architecture [47]. …

… Mutations in oncogenes and tumor suppressor genes are the main … genes, including TP53,
KRAS, PIK3A, and AR1D1A [50]. … colorectal cancer (Lynch syndrome) and microsatellite …

… four molecular subtypes: MSI, microsatellite stable/epithelial … normal mucosa to intestinal
metaplasia (Barrett’s esophagus or atrophic … of a series of tumor suppressor genes, resulting in …

… -associated preneoplastic and neoplastic lesions, their molecular … of TP53 dysregulation in
sporadic colon carcinogenesis, seminal … TP53 mutations and TP53 gene locus loss as early …