… APC is a tumor suppressor gene, member of the WNT pathway… of colorectal, gastric, small
intestinal, esophageal, and … : MLH1, MSH2, MSH6, and PMS2, leading to microsatellite …

… and silencing of tumor suppressor genes (TSG) [7]. … Reactivation of centromeric satellite
repeats (microsatellites) and … is also detectable in esophageal, gastric, colon, and renal cancer in …

… the proximal stomach in the absence of colorectal and … tumor suppressor genes, leading to
cancer initiation and progression; instability of repeat nucleotide sequences or microsatellites …

… accepted that cancer is a genetic disease that arises from the … clone carries a somatic TP53
mutation as initiating events), … of the pre-neoplastic or tumor samples analyzed. Many of the …

… oncogenes and tumor suppressor genes, including the genes for DNA … microsatellite DNA
instability in normal-appearing tissues adjacent to the tumor [22], suggesting that colorectal …

… in molecular biology facilitated genetic analyses and … 1), similar to the hematopoietic system
and intestinal epithelium [… of oncogenes and tumor suppressor genes in mouse models and …

… APC tumor-suppressor gene, which is the most common event … Microsatellite instability
analysis was performed using a … As in the stomach, which is the most frequent site of EBV+ …

… RNA expressions in the former (stomach origin) were associated with shorter survival and
a … of multiple microsatellite lesions, disrupting the function of tumor suppressor genes. MSI/…

… This was further supported by our selective analysis of genes involved in the TP53 … colon
and gastric cancer, whereas in colorectal cancer, KLF4 is regarded as a tumor suppressor gene …

… extra-colonic malignancies, such as stomach, small bowel, … non-coding microsatellite
regions (microsatellite instability; … upon mutations in major tumor suppressor genes, such as …