… the esophagus, stomach, pancreas, small intestine and colon; the … process through a series
of preneoplastic lesions. In … be the loss of the tumor suppressor gene Apc. The inactivation of …

… expression in esophageal cancer, and increased expression of Akt1/TP53 or low … ) gene
promoter[48] and tumor-suppressor gene adenomatous polyposis coli (APC)[49]. Microsatellite …

… the TP53 gene that encodes for tumor suppressor protein p53… in genes involved in DNA
damage response and microsatellite … , squamous lung, esophageal, and bladder carcinomas are …

… by epithelial cells in the stomach, small intestine, colon, and … Mutations in tumor suppressor
genes (TSGs) and oncogenes … OS and disease-free survival (DFS) than microsatellite stable …

… and EAC are TP53 (encoding the tumor suppressor p53) and … induced multifocal preneoplastic
lesions and liver cancer. 97 … (GC) compared with intestinal metaplasia of the stomach. …

… TP53 protein, encoded by a TP53 tumor suppressor gene, … epigenetic aberrations in
preneoplastic right colon mucosa [… microsatellite stable metastatic CRC, a right-sided disease is …

… Such genes may be tumor suppressor genes, oncogenes, … : Chromosomal instability (CIN),
microsatellite instability (MSI), … a wide variety of organs including stomach, lung, and ovary as …

… heterozygosity of the TP53 gene [32], microsatellite instability [33], … is dominated by tumor
suppressor genes with activating … neoplastic esophageal epithelium from patients with invasive …

… The existence of preneoplastic lesions in esophageal NETs (E… , as confirmed by microsatellite
marker analyses, and SCLCs … For instance, mutations in the TP53 tumor suppressor gene …

… observed no significant genetic or microsatellite instability (MSI… Barrett’s esophagus (BE) is
an intestinal metaplasia that … Oncogenic role: Tumor suppressor p53 induces cell apoptosis …