Molecular Identification of the Cyclic Peptide Hepatotoxins in Cyanobacteria

FS Idroos, PM Manage, SA Kulasooriya - … Sampling and Detection of …, 2023 - Springer
hepatotoxins. PCR is a well known as a technique to detect all potentially cyclic peptide
hepatotoxin (microcystin … insight into the evolution of the microcystin and nodularin synthetases, …

Isolation, molecular identification, and characterization of a unique toxic cyanobacterium Microcystis sp. found in Hunan Province, China

P Liu, J Wei, K Yang, IY Massey, J Guo… - Journal of toxicology …, 2018 - Taylor & Francis
… To distinguish between toxic vs non-toxic microcystin-producing abilities molecular
identification by amplifying 16S rDNA sequences and mcy genes was undertaken. Currently, PCR …

Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella

K Heck, DO Alvarenga, TK Shishido, AM Varani… - Toxicon, 2018 - Elsevier
characterization from a strain of the genus Fischerella, providing new insight into the
distribution and evolution … by the production of harmful toxic molecules that also have potential …

Microcystin biosynthesis and toxic effects

C Zhou, H Chen, H Zhao, Q Wang - Algal Research, 2021 - Elsevier
… , urban, and industrial development have increased the … cyanobacteria that can cause
hepatotoxicity in humans and … polypeptide with a predicted molecular weight of 430.2 kDa [63]. …

[HTML][HTML] Structural diversity, characterization and toxicology of microcystins

N Bouaïcha, CO Miles, DG Beach, Z Labidi, A Djabri… - Toxins, 2019 - mdpi.com
Hepatotoxic microcystins (MCs) are the most widespread class … number of publications on
these cyclic peptides increased [49]. … used for the identification of MCs have evolved as mass …

Overview of Toxic Cyanobacteria and Dinoflagellates and mcy Gene Clusters Responsible for Cyanotoxin Production

VW Lande - Journal of Indian Association for Environmental …, 2021 - op.niscpr.res.in
… During recent years, molecular biologist’s identified mcyA to … to produce hepatotoxin - a cyclic
heptapeptideof microcystins, [13… family has its own evolutionary phylogenetic tree history. It …

[HTML][HTML] The diversity of cyanobacterial toxins on structural characterization, distribution and identification: A systematic review

X Du, H Liu, L Yuan, Y Wang, Y Ma, R Wang, X Chen… - Toxins, 2019 - mdpi.com
… A cyclic peptide is a cyclic polypeptide chain formed by a … Microcystins (MCs) and nodularins
(NODs) are two classical … MCs are hepatotoxic cyclic heptapeptides. The general structure …

[HTML][HTML] Morphological and molecular identification of microcystin-producing cyanobacteria in nine shallow Bulgarian water bodies

M Radkova, K Stefanova, B Uzunov, G Gärtner… - Toxins, 2020 - mdpi.com
… of potent hepatotoxins—MCs and NODs—are produced through non-ribosomal peptide
[22,23] enabled the development of molecular detection methods for identifying all the main …

Microcystins and nodularins

A Catherine, C Bernard, L Spoof… - … and cyanotoxin analysis, 2016 - Wiley Online Library
Microcystins (MCs), a diverse family of cyclic heptapeptide hepatotoxins, are a group of …
origin, the NOD gene cluster having probably evolved from an MC synthetase [7]. In natural …

Nonribosomal peptide synthetases and nonribosomal cyanopeptides synthesis in Microcystis: A comparative genomics study

M Chen, C Xu, X Wang, Y Wu, L Li - Algal Research, 2021 - Elsevier
Microcystins are a group of hepatotoxic cyclic heptapeptides that … in Microcystis are related
to evolutionary history and … to using molecular detection in the management of Microcystis