Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury

G Musch - Frontiers in Physiology, 2023 - frontiersin.org
glucose transport (k 1 ) and phosphorylation (k 3 ) in acutely injured … mice who had received
intratracheal endotoxin confirmed higher pulmonary uptake of 18 F-NOS than in control mice

… -[18F]fluoro-D-glucose Positron Emission Tomography to Monitor Lung Inflammation and Therapeutic Response to Dexamethasone in a Murine Model of Acute Lung …

PZ Mannes, CE Barnes, JD Latoche, KE Day… - Molecular Imaging and …, 2023 - Springer
… influx and glucose metabolism in inflamed tissues, [ 18 F]FDG PET is a … with intrabronchial
endotoxin [11]. Interestingly, [ 18 F]FDG … radiotracer uptake in the lungs of LPS-treated mice as …

18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury

RS Rodrigues, FA Bozza, CJ Hanrahan… - Nuclear medicine and …, 2017 - Elsevier
Molecular imaging of the earliest events related to the … of 18 F-FDG uptake, edema and
neutrophil recruitment in an endotoxin-… of specific molecular determinants of glucose uptake with …

A window on the lung: Molecular imaging as a tool to dissect pathophysiologic mechanisms of acute lung disease

G Musch - Contrast Media & Molecular Imaging, 2019 - Wiley Online Library
glucose metabolism, in the diagnosis and monitoring of lung … Because endotoxin is
known to blunt hypoxic pulmonary … to measure regional pulmonary perfusion in rats [42]. …

Molecular imaging of pulmonary inflammation and infection

C Giraudo, L Evangelista, AS Fraia, A Lupi… - … Journal of Molecular …, 2020 - mdpi.com
… -NOS PET/CT for endotoxin-induced lung inflammation in … PET/CT, providing information
about the glucose metabolism, is highly reliable to detect active lesions for several types of lung

… tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET …

I Luna-Reyes, EG Pérez-Hernández… - Scientific Reports, 2021 - nature.com
… On the other hand, since the parameter of respiratory frequency … PET equipment, originally
designed to study mice and rats. … of the administration of LPS employing micro-PET imaging. …

Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

T Suzuki, Y Tada, S Gladson, R Nishimura… - Respiratory …, 2017 - Springer
… EndMT was observed in mice with septic acute lung injury (ALI) that … of pulmonary fibrosis
in systemic endotoxin-induced ALI. In the pulmonary fibrosis model after systemic endotoxemia

Metabolic imaging and biological assessment: platforms to evaluate acute lung injury and inflammation

M Pourfathi, SJ Kadlecek, S Chatterjee… - Frontiers in …, 2020 - frontiersin.org
… -of-the-art molecular imaging techniques that are currently used pre-… glucose uptake was
significantly elevated in lungs of human subjects 24 h after instillation of 1–4 ng/kg endotoxin in …

Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung …

W Deng, CY Li, J Tong, J He… - Molecular Medicine …, 2019 - spandidos-publications.com
… effect rather than an effect on the modulation of glucose metabolism, since it was observed
that insulin treatment did not affect the glucose levels in the LPS-induced lung injury group. …

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

L Wang, Y Cao, B Gorshkov, Y Zhou, Q Yang… - Pharmacological …, 2019 - Elsevier
lung from Pfkfb3 WT mice and Pfkfb3 ΔVEC mice after vehicle or 1 mg/kg LPS injection by it
for 6 h. The EBA content of lung … of lung tissue from Pfkfb3 WT and Pfkfb3 ΔVEC mice after