Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: a review

S Amir, STA Shah, C Mamoulakis, AO Docea… - International Journal of …, 2021 - mdpi.com
chemicals (EDCs) is one of the major causes of reproductive … it is still able to induce the
estrogenic effects at very low … their exact interaction with molecular mechanisms involved in the …

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

S Sifakis, VP Androutsopoulos, AM Tsatsakis… - Environmental …, 2017 - Elsevier
… The molecular mechanism of action of EDCs with regard to the disorders of the … with the
estrogen receptor (ER). Environmental pollutants, such as TCDD can induce the expression of …

Endocrine disruptors and endometrial cancer: molecular mechanisms of action and clinical implications, a systematic review

D Caserta, MP De Marco, AR Besharat… - … Journal of Molecular …, 2022 - mdpi.com
… limbs and oedema in the external genitalia must lead to a … and the high prevalence of
estrogen-dependent forms in this … of mycotoxin-induced estrogenicity, significantly suppressing …

Endocrine-disrupting chemicals and their effects during female puberty: a review of current evidence

L Lucaccioni, V Trevisani, L Marrozzini… - … Journal of Molecular …, 2020 - mdpi.com
… in the environment as a persistent organic pollutant (POP). … can induce aromatase activity,
increasing the level of estrogen … a mixture of EDCs on female sexual development over three …

Peripheral and central mechanisms involved in the hormonal control of male and female reproduction

LM Rudolph, GE Bentley, RS Calandra… - Journal of …, 2016 - Wiley Online Library
… the molecular mechanisms involved in the central and peripheral hormonal control of …
and nuclear oestrogen receptors. During di-oestrus, classical nuclear E 2 signalling induces

REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways

HB Patisaul - Reproduction, 2021 - rep.bioscientifica.com
… signs that show reproductive health is declining as chemical … other persistent organic
pollutants to reduced fertility in birds, … to the nucleus inducing transcriptional changes in estrogen-…

New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs

T Iguchi, T Sato, T Nakajima, S Miyagawa, N Takasugi - Differentiation, 2021 - Elsevier
… to various estrogenic chemicals. Ten years later, vaginal cancers were reported in young …
molecular mechanism underlying the persistent vaginal changes induced by perinatal estrogen

Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin αvβ3

Z Sheng, C Wang, F Ren, Y Liu, B Zhu - Journal of Environmental Sciences, 2019 - Elsevier
… BPA has similar chemical structure with the natural estrogen … and functional regulation of
the reproductive system. Therefore, the … concentration of estrogen plus BPA could change the …

Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction

R Meli, A Monnolo, C Annunziata, C Pirozzi… - Antioxidants, 2020 - mdpi.com
… have examined the underlying molecular mechanisms of BPA … of antioxidant substances
on the BPA-induced toxicity and … females, these actions induce several changes in estrogen-…

Environmental factors, epigenetics, and developmental origin of reproductive disorders

SM Ho, A Cheong, MA Adgent, J Veevers… - Reproductive …, 2017 - Elsevier
… , reproductive tract structures, and external genitalia. As the … Fetal exposure to environmental
chemicals with estrogenic … of reprogramming, may induce profound changes in regulatory …