… bryostatin 1 and related analogs. Chapter 2 details the collaborative total synthesis effort to
produce bryostatin 1 … way (19 longest linear sequence, 29 total steps) with a 4.8% yield. This …

… Chapter 5 details the total synthesis of bryostatin 1. Through the … evaluations of C9-deoxy
bryostatin 1. Angew. Chem. … oriented synthesis: preparation and initial biological evaluation of …

… for conducting biological evaluations, high overall yields to the … enabled by diverted total
synthesis provide a unique … structurally related macrocyclic analogues of bryostatin 1 (18, Figure …

… bryostatin 1 is through the total synthesis developed in our lab (Scheme 1). Our convergent
… (6b) Studies on such analogues and their biological evaluations will be reported in due …

… Total synthesis of bryostatin 9 by Wender and Schrier ....................................... 95 3.2.3 Total
synthesis of bryostatin 1 … Preliminary biological evaluation of tigliane analogs in binding assay …

… The details of total synthesis were also reviewed recently by … members (bryostatin 1-21) of
this family have been isolated [… Synthesis and biological evaluation of bryostatin analogues: …

… interest in bryostatin 1, attention has been focused on the synthesis of … Biological evaluation
indicates that significant binding affinity … Molecular modeling studies indicate that the planer …

… for the total synthesis of bryostatins. Further modification of … Biological evaluation of this
focused small library revealed … cell lines, with dysidiolide‐like molecule 57 being the most potent …

… and drug discovery, we use the term “total synthesis” in a rather general sense – when
presenting syntheses of such complex target molecules as marine toxins, chiral pool is amply …

… (SAR) of bryostatin 1 promises extraordinary benefits to our … des-methyl bryostatin analogue
and its biological evaluation. A … was made during the total synthesis of a novel analogue. It …