… to be correlated with adaptive tumor cell drug resistance. The dynamic transcriptional
nature of the kinome also differs for inhibitors targeting different kinase signaling pathways (eg, …

… of mitochondria in tumor adaptation to molecular therapy. We … -molecule inhibitors of the
PI3K (24), Akt, and mTOR pathway … therapeutic inhibition of pyruvate dehydrogenase kinase (…

… The successful therapeutic targeting of a kinase by a small-molecule inhibitor is highlighted
by the 2001 FDA approval of imatinib in chronic myelogenous leukemia (CML). Imatinib is a …

… of molecular drivers of cancer and development of targeted drugs … pathway inhibition, as
well as overcoming the issue of heterogeneity in the adaptive kinome reprogramming response. …

… dynamics modulate time to recurrence in continuous and adaptive cancer therapies. … that
targets key kinase signaling networks rather than individual kinases or signaling pathways, as a …

… specific bypass signaling pathways induced in response to TKI-stimulated cellular
reprogramming, … readers to prevent kinome reprogramming blocked outgrowth of adapted cancer …

… that CSNK2 inhibition may be effective to combat adaptive … with CX-4945 or siRNA targeting
CSNK2A1 promoted higher … that the kinome had adapted in response to Bcr-Abl inhibition by …

… inhibitor beads (MIBs) and mass spectrometry, we demonstrate that BETi resistance is mediated
by adaptive kinome reprogramming… Hippo-signaling pathway was confirmed by western …

… As regulators of cellular homeostasis, characterizing the molecular players responsible for
the adaptive response as well as identifying the extent that proteins not looked at in this study …

… In addition, molecular studies were conducted on four sensitive parental … Targeting specific
oncoproteins crucial for tumour growth, such as BRAF, induces adaptive kinome responses …