[HTML][HTML] How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane

J Hong, X Lu, Z Deng, S Xiao, B Yuan, K Yang - Molecules, 2019 - mdpi.com
… to the membrane insertion behavior of melittin mostly from a computational aspect. Membrane
… were further made to understand the molecular mechanism of melittin interaction with cell …

[HTML][HTML] Molecular details on the intermediate states of melittin action on a cell membrane

J Liu, S Xiao, J Li, B Yuan, K Yang, Y Ma - Biochimica et Biophysica Acta …, 2018 - Elsevier
… In this paper, the intermediate transition between the initial peptide binding and final insertion
states during melittin-membrane interaction process is investigated, by a combination of …

[HTML][HTML] How does melittin permeabilize membranes?

WC Wimley - Biophysical Journal, 2018 - cell.com
… the molecular mechanism of action of melittin and other … by sudden, cooperative peptide
translocation events ( … interactions of melittin with the outer membrane (OM) and the cytoplasmic …

Molecular simulations of melittin-induced membrane pores

D Sun, J Forsman, CE Woodward - The Journal of Physical …, 2017 - ACS Publications
… that it is the interactions between the predominately hydrophobic melittin N-terminus and …
Cooperative antimicrobial action of melittin on lipid membranes: A coarse-grained molecular

Stability of Colloids in Negatively Cooperative Melittin–Phospholipid

F Torrens Zaragozá - Nereis, 2018 - riucv.ucv.es
… the aggregation of melittin molecules. Such aggregation … multilayer formation of melittin on
phospholipid membranes. … is difficult to distinguish if melittin interacts with the initially provided …

[HTML][HTML] Organizations of melittin peptides after spontaneous penetration into cell membranes

L Sun, S Wang, F Tian, H Zhu, L Dai - Biophysical Journal, 2022 - cell.com
… In this work, we use multiscale molecular dynamics simulations to investigate the melittin
We choose six simulations to calculate the energies of LJ and electrostatic interactions. …

Applications and evolution of melittin, the quintessential membrane active peptide

S Guha, RP Ferrie, J Ghimire, CR Ventura, E Wu… - Biochemical …, 2021 - Elsevier
… action of the C-terminal melittin sequence through electrostatic interactions with the five basic
residues of … In solution, melittin molecules are monomeric and have random coil structure …

Residue-specialized membrane poration kinetics of melittin and its variants: insight from mechanistic landscapes

ZX Deng, JL Li, B Yuan, K Yang - Communications in Theoretical …, 2019 - iopscience.iop.org
… inter-molecular cooperation; the probable reaction pathway and … In this work, the membrane
interaction process of melittin and … , the characteristic behaviors (eg membrane thinning and …

Role of the cationic C-terminal segment of melittin on membrane fragmentation

A Therrien, A Fournier, M Lafleur - The Journal of Physical …, 2016 - ACS Publications
interactions involving the C-terminal charges of melittin in the lipid extraction induced upon
interacting with membranes. … enrichment near the membrane-inserted melittin molecules, a …

Dynamic structure and orientation of melittin bound to acidic lipid bilayers, as revealed by solid-state NMR and molecular dynamics simulation

K Norisada, N Javkhlantugs, D Mishima… - The Journal of …, 2017 - ACS Publications
melittin molecule in the DMPG membranes is controlled, we analyzed the interactions between
melittin and lipid molecules. … data for the interaction energy of the melittin peptide with the …