Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612
individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci,
bringing the total to 32. We further found shared genetic variation with related vascular traits,
including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n=
18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612
individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci,
bringing the total to 32. We further found shared genetic variation with related vascular traits,
including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n=
18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
R Rabionet Janssen - Nature Genetics, 2019, vol. 50, p. 524-537, 2019 - diposit.ub.edu
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612
individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci,
bringing the total to 32. We further found shared genetic variation with related vascular traits,
including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n=
18), and using genetic risk scores and linkagedisequilibrium-score regression. Several loci …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612
individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci,
bringing the total to 32. We further found shared genetic variation with related vascular traits,
including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n=
18), and using genetic risk scores and linkagedisequilibrium-score regression. Several loci …
以上显示的是最相近的搜索结果。 查看全部搜索结果