… A major role in cell survival is believed to rely on CK2 modulation of caspase activity [67,68,…
Recently, our group has shown that protein kinase CK2 sustains the growth of many blood …

… kinases may profoundly influence MM cells survival … cells could depend on different
mechanisms: (i) induction by the autophagic stimuli of new p62 synthesis, replacing the p62 protein …

… that protein kinase CK1α may support the growth of multiple … that CK1α activity is essential
for malignant plasma cell survival … AKT on Ser473, which depends on mTOR activity [3]. Both β-…

… CK1α and CK2 are overactive in multiple myeloma, … In humans, protein kinase CK2 exists
as a tetrameric enzyme, … in cancer cell biology, tumor cell survival and clonal expansion rely on …

… that cancer cells rely on CK2 activity more than healthy cells, … CK2 is an anti-apoptotic kinase,
which sustains cell survival … In addition to its function in protecting cells from the cytotoxic …

… those encoding kinases, critical for myeloma cell survival have given … protein kinase
targets described in this review are phosphoinositide 3-kinase (PI3K) and sphingosine kinase…

… signal relies on the interplay involving CK2 and protein … lymphocytic leukemia cells
significantly reduces cell viability. … instances, induces cell death in various myeloma cell lines and …

… extent, depends upon, how it modulates key signaling … tumor cell proliferation with no
effects on cell survival nor … (CMD) and multiple myeloma (MM), CK2 regulates the activation …

… Moreover, the use of crizotinib in the TAPUR trial is based on MET mutations in addition to
… -2 is highest expressed in MM. Functionally, it triggers MM cell survival and proliferation by …

… cells has further demonstrated that activity from a CK2 catalytic subunit is necessary for cell
survival… in conjunction with the consistent reliance of cancer cells on elevated CK2 levels has …