… Switch regions (switch I and II) of Rabs are known to … this mechanism is applicable to all
Rabs remains unclear. Active … The functions of these ‘large Rab GTPases’ have only recently …

… sensitive switch regions (switches 1 and 2) of Rabs undergo … In contrast, the α3-β5 loop
is targeted by only a few kinases (… In summary, many of the phospho-Rabs in Table 1 have …

… of Rab GTPases, or the membrane compartments they regulate, are associated with virtually
all neuronal activities in health and disease. The observation that many Rab GTPases are …

… system consists of multiple interconnected organelles. Rab GTPases are organelle-specific …
Yet our insights on the specific membrane targeting and regulation of GEFs remain …

… GTPases to control vesicle aggregation, fusion, and targeted transport, how it controls metabolic
and signaling pathways, and the temporal and spatial control of its function are all … region…

… (active) Rab conformation is recognized by multiple effector … disordered region of Rab also
contributes to membrane … Membrane targeting mechanism of Rab GTPases elucidated by …

… differ in the structure of two loop regions termed ‘switch I’ and ‘… sites for multiple Rabs and
thus can bridge two membranes of … orchestrate Rab GTPase function, membrane targeting of …

… Therefore, targeting Rab GTPases to adjust membrane … Many studies have indicated that
different Rab GTPases … Through specific binding to the two switch regions, GAPs and GEFs …

… RAB targeting to membranes. Pereira-Leal and Seabra6 identified five RAB family regions
that distinguish RAB … the last 20 amino acids of all human RAB proteins, we found that RAB23 …

… At the C-terminus, Rab proteins contain a hypervariable region, which was … membrane
targeting seems to be regulated by a more complex mechanism involving different regions of Rab …