… Cullin-RING E3 ubiquitin ligase function and substrate … (almost) the entire COP9 signalosome
and a SMAP1-related … of free NEDD8 rather than impaired AXR1 function must be at the …

… investigated the function of a RING-type E3 ligase gene, SRAS1, which generated two transcript
… provide novel insights into the AS-mediated post-transcriptional regulation of E3 ligase. …

… play a central role in the selectivity of ubiquitin-mediated protein … We also highlight many
outstanding questions that await … How these two E3 ligases regulate LFY function is unknown …

… function, and it may provide insights and implications for the regulation of other dynamic
multi-unit complexes involved in fundamental processes … ) that contains the AXR1 and ECR1 …

… of functional redundancy between both genes regarding two … a SUMO (Small Ubiquitin-like
Modifier) E3 ligase necessary for the … CtIP-mediated DNA end resection 27 and promoting Ku …

… There are several reports demonstrating the role of different … The COP1 protein acts as E3
ubiquitin ligase for proteolytic … AXR1 protein shares high sequence homology to E1. Further …

… expression of 71 potential E3 ligase genes in meiocytes, and … COP9 signalosome interacting
F_box Kelch 1 (CFK1), one of … to demonstrate a regulatory role for AXR1 in pericentromeric …

… adaptor modules function as complex RING-type E3 ligases and … In Arabidopsis, ECR1 and
AXR1 or AXL form a heterodimeric … (DEN1) and the COP9 signalosome (CSN) have Nedd8-…

… proteasome lid (LID), the COP9 signalosome (CSN), and the … a novel functional link between
the COP1 ubiquitin ligase and … on the AXR1/NCE2 NEDDylation machinery. An essential …

… ), are required to control ubiquitin ligase assembly, function, and … We find that AXR1 as
well as other neddylation enzymes are … deneddylases DEN1/DenA and COP9 signalosome. …