How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches

YS Mineur, MR Picciotto - Journal of neurochemistry, 2023 - Wiley Online Library
… with a generic postsynaptic cholinoceptive cell, with labeling … disorders, such as Alzheimer's
disease, Parkinson's disease, … VAChT), or nicotinic and muscarinic ACh receptors, have also …

… molecular docking and dynamic simulation of anti-cholinesterase compounds from the extract of Catunaregam spinosa for possible treatment of Alzheimer's disease

S Thandivel, P Rajan, T Gunasekar, A Arjunan, S Khute… - Heliyon, 2024 - cell.com
… This loss is linked to cortical cholinergic axons and cholinoceptive neurons, while
cholinesterase activity emerges in AD cortex, linked to plaques, tangles, and amyloid angiopathy. …

[PDF][PDF] Perspectives of Presynaptic Autoreceptors and Presynaptic Heteroreceptors in the Mechanism of Neurotransmission

SP Gawade - … Journal of Pharmaceutical Education & Research, 2022 - ijper.org
… in prefrontal cortex was significantly increased by AF-DX116.… neuron by interacting with M
2 and M 4 muscarinic auto … In the context of nonavailability of the postsynaptic cholinoceptive

Nitric oxide donor molsidomine promotes retrieval of object recognition memory in a model of cognitive deficit induced by 192 IgG-saporin

MA Hernández-Melesio, M Alcaraz-Zubeldia… - … brain research, 2019 - Elsevier
… and nNOS in fresh tissues from rat prefrontal cortex (PC), HC, … cholinoceptive hippocampal
region and the striatal medium spiny … Muscarinic–but not nicotinic–acetylcholine receptors …

CSF and plasma cholinergic markers in patients with cognitive impairment

A Karami, T Darreh-Shori, M Schultzberg… - Frontiers in Aging …, 2021 - frontiersin.org
neurons and that stimulates a diverse array of muscarinic and … Early findings of the loss of
cholinergic neurons and marked … first drugs available for pharmacological treatment of AD, the …

Role of the locus coeruleus and basal forebrain in arousal and attention

EB Maness, JA Burk, JT McKenna, FL Schiffino… - Brain research …, 2022 - Elsevier
… depolarize cortical interneurons, and G protein-coupled muscarinic … of cholinoceptive cortical
and thalamocortical neurons is … -cortical interactions of the frontal lobe with primary sensory …

The Role of the Cholinergic System in Lung Diseases

V Milankovic, T Lazarevic-Pasti - … Signalling Pathways in Lung Diseases, 2021 - Springer
… AChE is consistently associated with both cholinergic and cholinoceptive neurons. At the …
and released by neuronal and non-neuronal sources and their action on muscarinic receptors. …

Potential cardiologic protective effects of acetylcholinesterase inhibitors in patients with mild to moderate dementia

L Rampa, R Santangelo, C Gaspardone… - The American Journal of …, 2023 - Elsevier
… because of the peripheral muscarinic M2 receptor stimulation. … neurons from the nucleus
basalis of Meynert 5 is associated with the cognitive impairment observed in Alzheimer disease (…

[图书][B] CNS Neurotransmitters and Neuromodulators: Acetylcholine

TW Stone - 2020 - books.google.com
… , and muscarinic binding sites) in the cerebral cortex was … 30% of neocortical neurons is
cholinoceptive, and for most of … of its degeneration in Alzheimer's disease and the dementia …

[PDF][PDF] The neurobiology of acetyl-L-carnitine

G Traina - Front Biosci (Landmark Ed), 2016 - peirsoncenter.com
… that ALC is a weak muscarinic receptor agonist (14). … mGlu2 receptor expression in the
prefrontal cortex (6). Summing … NGF affects neuronal development and maintenance of neurons