Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease
Alzheimer’s disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease. …
despite extensive research, only a few drugs are available for management of the disease. …
Riluzole ameliorates learning and memory deficits in Aβ25-35-induced rat model of Alzheimer's disease and is independent of cholinoceptor activation
Z Mokhtari, T Baluchnejadmojarad, F Nikbakht… - Biomedicine & …, 2017 - Elsevier
… and may be of benefit in Alzheimer's disease. In the present study, … In this research study,
number of Nissl-stained neurons per … suggest no involvement of muscarinic or nicotinic receptor …
number of Nissl-stained neurons per … suggest no involvement of muscarinic or nicotinic receptor …
Current state of research on non‐human primate models of Alzheimer's disease
HW Li, L Zhang, C Qin - Animal models and experimental …, 2019 - Wiley Online Library
… Alzheimer's disease (AD), also known as Alzheimer's … encompass the marginal cortex and
prefrontal lobe, and not the … the decrease of the muscarinic cholinoreceptor. Scopolamine can …
prefrontal lobe, and not the … the decrease of the muscarinic cholinoreceptor. Scopolamine can …
[HTML][HTML] Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias
… Alzheimer's disease is a neurodegenerative disease that … -β protein plaques in neurons and
hyperphosphorylation of … in long-term depression in the prefrontal cortex and the potential for …
hyperphosphorylation of … in long-term depression in the prefrontal cortex and the potential for …
Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: A unifying hypothesis
… of the prefrontal cortex and parietal association areas display the … of neuronal precursors
supplying neurons to expanding … [91], activation of M1 and M3 muscarinic AChR suppresses the …
supplying neurons to expanding … [91], activation of M1 and M3 muscarinic AChR suppresses the …
Cholinergic modulation of the hippocampal region and memory function
J Haam, JL Yakel - Journal of neurochemistry, 2017 - Wiley Online Library
… and RNA processing in the prefrontal cortex (Martyn et al. 2012; … to modulate the neuronal
activity in the entorhinal cortex (EC), … circuits: implications for treatment of Alzheimer disease. …
activity in the entorhinal cortex (EC), … circuits: implications for treatment of Alzheimer disease. …
Cholinesterase inhibitors for Alzheimer's disease: multitargeting strategy based on anti-Alzheimer's drugs repositioning
MT Kabir, MS Uddin, M Begum… - Current …, 2019 - ingentaconnect.com
… AD patients suffer loss of ACh in cholinergic neurons and this results in the impairment of
cognitive functions. Furthermore, loss of cholinergic neurons in the … In the brain, the muscarinic …
cognitive functions. Furthermore, loss of cholinergic neurons in the … In the brain, the muscarinic …
Functional characterization of acetylcholine receptors expressed in human neurons differentiated from hippocampal neural stem/progenitor cells
K Fukushima, K Yamazaki… - Journal of …, 2016 - journals.sagepub.com
… muscarinic AChRs (nAChRs and mAChRs, respectively) in human hippocampal neurons …
prefrontal cortex, functionally express nAChRs. In these studies, however, the iPSC-derived …
prefrontal cortex, functionally express nAChRs. In these studies, however, the iPSC-derived …
Pharmacological effects of turmeric on learning, memory and expression of muscarinic receptor genes (M1, M3 and M5) in stress-induced mouse model
A Khalid, R Shakeel, S Justin, G Iqbal… - Current Drug …, 2017 - ingentaconnect.com
… Briefly, hippocampus and prefrontal cortex were dissected and … Cholinergic neurons are
widely distributed in cortex and … use of turmeric in Alzheimer's disease. Pharmacol Biochem …
widely distributed in cortex and … use of turmeric in Alzheimer's disease. Pharmacol Biochem …
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review
M Golmohammadi, M Mahmoudian… - Fundamental & …, 2024 - Wiley Online Library
… The initial stage involves the accumulation of granular tau oligomers in the frontal cortex, …
and muscarinic acetylcholine receptors due to marked degeneration of cholinergic neurons …
and muscarinic acetylcholine receptors due to marked degeneration of cholinergic neurons …