Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia

P Zhuang, J Zhang, Y Wang, M Zhang, L Song… - Supportive Care in …, 2016 - Springer
… Grip strength reflects the extent of the damage in skeletal muscle, as evidenced by a voluntary
… Several reports suggested that impairment of IGF-1 signaling may result in muscle atrophy

Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial

C Grunseich, R Miller, T Swan, DJ Glass… - The Lancet …, 2018 - thelancet.com
… The results of this trial indicate that IGF-1 pathway activation … for patients with spinal and
bulbar muscular atrophy. TMV can be … Serum concentrations of BVS857 and endogenous IGF-1

[HTML][HTML] IGF-1 and IGFBP-3 in Inflammatory Cachexia

AI Martín, T Priego, Á Moreno-Ruperez… - International Journal of …, 2021 - mdpi.com
… Catabolism, body weight loss, growth impairment, muscle atrophy, … serum concentration of
IGF-1 and its synthesis in the liver … to activate muscle proteolysis. Finally, as observed in liver …

Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction

L Feng, B Li, Y Xi, M Cai, Z Tian - American Journal of …, 2022 - journals.physiology.org
… with skeletal muscle abnormalities, including atrophy, which has been … related to the activation
of endogenous IGF-1 by exercise or … skeletal muscle atrophy, activation of IGF-1 signaling, …

An overview of muscle atrophy

S Ding, Q Dai, H Huang, Y Xu, C Zhong - Muscle Atrophy, 2018 - Springer
muscle tissue compared to placebo counterparts. Moreover, serum TNF-α and IGF-1
concentrations were decreased … risk of cancer and multiple behavior abnormalities prevent it from …

[HTML][HTML] Sustained systemic levels of IL-6 impinge early muscle growth and induce muscle atrophy and wasting in adulthood

L Pelosi, MG Berardinelli, L Forcina, F Ascenzi… - Cells, 2021 - mdpi.com
… and the local impairment of the physiologic muscle redox balance… they innervate by
selective activation of fiber specific gene … of growth factors (IGF-1) [50,51]. However, although …

Effects of different modes of exercise on skeletal muscle mass and function and IGF-1 signaling during early aging in mice

B Li, L Feng, X Wu, M Cai, JJ Yu… - Journal of Experimental …, 2022 - journals.biologists.com
… a direct link between activation of IGF-1 signaling and skeletal muscle hypertrophy in early …
effectively reduce the incidence of skeletal muscle atrophy and complications in later old age, …

Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise

WJ Kraemer, NA Ratamess… - Journal of Applied …, 2017 - journals.physiology.org
… homeostasis following a transient disturbance. Exercise is a … Serum concentrations of free
testosterone have been shown to … activate IGF-1 synthesis in local tissues. Many aspects of …

The clinical relevance and mechanism of skeletal muscle wasting

K Duan, X Gao, D Zhu - Clinical Nutrition, 2021 - Elsevier
… During resistance training, increased PCG1α4 could mediate the activation of IGF-1, lead
to muscle hypertrophy [122]. In addition, clinical studies have implied exercise may improve …

[HTML][HTML] Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of …

M Hofmann, B Schober-Halper, S Oesen… - European journal of …, 2016 - Springer
muscle growth through the IGF-1 pathway. As plasma … While the activation of the
phosphoinositide 3-kinase (PI3K)/… changes of T3-T1 in muscle mass and serum levels of myostatin …