Efficacy and safety of N-acetylcysteine as add-on therapy in the treatment of obsessive-compulsive disorder: A systematic review and meta-analysis

AHA Gadallah, MA Ebada, A Gadallah… - … Obsessive-Compulsive …, 2020 - Elsevier
… We selected relevant randomized clinical studies discussing NAC in patients with OCD. We
selected eligible studies, independently extracted the data, individually evaluated the quality …

Nacetylcysteine augmentation therapy for moderate‐to‐severe obsessivecompulsive disorder: Randomized, double‐blind, placebo‐controlled trial

K Paydary, A Akamaloo, A Ahmadipour… - Journal of clinical …, 2016 - Wiley Online Library
… tolerability as well as its good safety profile and lack of significant interaction with standard
OCD medications further highlight its potential benefits as add-on therapy for refractory OCD. …

Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder

DLC Costa, JB Diniz, G Requena… - The Journal of clinical …, 2017 - psychiatrist.com
Objective: To evaluate the efficacy of serotonin reuptake inhibitor (SRI) augmentation with N-acetylcysteine
(NAC), a glutamate modulator and antioxidant medication, for treatment-…

Augmentation therapy of N-acetylcysteine for OCD: A meta-analysis of double-blind, randomized, placebo-controlled trials

E Noskova, P Stopkova, J Horacek, A Sebela - … of Obsessive-Compulsive …, 2019 - Elsevier
Treatment resistance is a barrier to the successful care of patients with OCD. Glutamate
modulators such as n-acetylcysteine (NAC) represent a promising new treatment option. To …

N-acetyl cysteine (NAC) augmentation in the treatment of obsessive-compulsive disorder: A phase III, 20-week, double-blind, randomized, placebo-controlled trial

J Sarris, G Byrne, D Castle, C Bousman, G Oliver… - Progress in Neuro …, 2022 - Elsevier
… Preliminary evidence has suggested that adjunctive N-acetylcysteine (NAC), an antioxidant
… of obsessive-compulsive disorder (OCD). We conducted a 20-week, multi-site, randomized

Oral N-acetylcysteine in the treatment of obsessive-compulsive disorder: a systematic review of the clinical evidence

JP Couto, R Moreira - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
… NAC add-on therapy might be a potential pharmacological approach to treatment-resistant …
age of 31 years, were randomized into two equal groups and treated with SSRIs, at the same …

Participant characteristics as modifiers of response to N-acetyl cysteine (NAc) in obsessive-compulsive disorder

J Sarris, G Oliver, DA Camfield… - Clinical Psychological …, 2016 - journals.sagepub.com
… , only a handful of which may have been randomized into the current study. Furthermore, the
form … N-acetylcysteine augmentation in treatment resistant obsessive compulsive disorder: A …

N-Acetylcysteine for obsessive-compulsive and related disorders in children and adolescents: A review

GM Parli, MA Gales, BJ Gales - Annals of Pharmacotherapy, 2023 - journals.sagepub.com
… Ghanizadeh et al 17 conducted a 10-week, randomized, double-blind, placebo-controlled,
multi-center clinical trial analyzing the effect of NAC as add-on therapy to SSRI therapy in 34 …

N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial

MH Bloch, KE Panza, A Yaffa… - Journal of child and …, 2016 - liebertpub.com
… Our findings stand in contrast to studies suggesting benefits of NAC in the treatment of other
obsessive-compulsive spectrum disorders in adults, including OCD and trichotillomania, but …

N-acetylcysteine for pediatric obsessive-compulsive disorder: a small pilot study

F Li, MC Welling, JA Johnson, C Coughlin… - Journal of Child and …, 2020 - liebertpub.com
… Bloch MH, Panza KE, Grant JE, Pittenger C, Leckman JF: N-Acetylcysteine in the treatment
of pediatric trichotillomania: A randomized, double-blind, placebo-controlled add-on trial. J …