WASP and Mst1 coregulate B-cell development and B-cell receptor signaling
… signaling and the key upstream molecules of BCR signaling (… immunoglobulin G (IgG; lane
1, serving as negative control) … Even the deletion of WASP and N-WASP has no effect on the …
1, serving as negative control) … Even the deletion of WASP and N-WASP has no effect on the …
The role of WASp in T cells and B cells
… is required for many cellular processes of T cells and B cells like … for T cell development for
the compensatory role of N-WASp, the … A study has identified the negative regulator Bruton’s …
the compensatory role of N-WASp, the … A study has identified the negative regulator Bruton’s …
WASP family proteins regulate the mobility of the B cell receptor during signaling activation
… B cells are an important component of the adaptive immune … They link receptor signaling to
actin dynamics through the activation … B cells from N-WASP conditional knockout mice exhibit …
actin dynamics through the activation … B cells from N-WASP conditional knockout mice exhibit …
N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome
… the B-cell-specific promoter mb1. Here we show that deletion of N-WASP in B cells impairs
B-cell activation and T-cell-… manifestations of immune dysregulation seen in B/WcKO mice. …
B-cell activation and T-cell-… manifestations of immune dysregulation seen in B/WcKO mice. …
CD23 can negatively regulate B-cell receptor signaling
C Liu, K Richard, M Wiggins, X Zhu, DH Conrad… - Scientific reports, 2016 - nature.com
… remodeling is critical for the initiation and regulation of the … CD23 in the negative regulation
of BCR signaling induced by … CD23 can exert its negative regulatory function without being …
of BCR signaling induced by … CD23 can exert its negative regulatory function without being …
The coordination between B cell receptor signaling and the actin cytoskeleton during B cell activation
…, Z Yu, Z Peng, X Li, Y Wen, X Sun, B Ren… - Frontiers in …, 2019 - frontiersin.org
… is not required by B cell during antigen recognition (7), so … that during BCR signaling
attenuation, neural WASP (N-WASP), … Abp1 was found negatively regulate T-cell signaling through …
attenuation, neural WASP (N-WASP), … Abp1 was found negatively regulate T-cell signaling through …
N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters
A Bhanja, MK Seeley-Fallen, M Lazzaro, A Upadhyaya… - Elife, 2023 - elifesciences.org
… an important study highlighting a distinct role of WASP dependent actin foci in B cell antigen
receptor signalling… SHIP-1 and SHP-1 negatively regulate BCR signaling by inactivating the …
receptor signalling… SHIP-1 and SHP-1 negatively regulate BCR signaling by inactivating the …
N-WASP regulates the mobility of the B cell receptor and co-receptors during signaling activation
… in the context of immune receptor signaling. The binding of … B cells are an important component
of the adaptive immune … , we hypothesized that N-WASP mediated actin regulation will …
of the adaptive immune … , we hypothesized that N-WASP mediated actin regulation will …
[HTML][HTML] Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification
M Descatoire, R Fritzen, S Rotman, G Kuntzelman… - Cell Reports, 2022 - cell.com
… A key contribution of B cells to development … B cell responses remain T cell dependent in
constitutive WASp-deficient mice, whereas selective WASp deletion in germinal center B cells (…
constitutive WASp-deficient mice, whereas selective WASp deletion in germinal center B cells (…
The regulators of BCR signaling during B cell activation
…, X Li, Z Peng, X Sun, H Miller, Z Sui, Q Gong, B Ren… - Blood Science, 2019 - mednexus.org
… BCR signaling is essential for normal B cell development and … N-WASP.66 This mechanism
may also be related to the … In mIgM-expressing B cells, Grb2 is a negative regulator that …
may also be related to the … In mIgM-expressing B cells, Grb2 is a negative regulator that …