… signaling and the key upstream molecules of BCR signaling (… immunoglobulin G (IgG; lane
1, serving as negative control) … Even the deletion of WASP and N-WASP has no effect on the …

… is required for many cellular processes of T cells and B cells like … for T cell development for
the compensatory role of N-WASp, the … A study has identified the negative regulator Bruton’s …

… B cells are an important component of the adaptive immune … They link receptor signaling to
actin dynamics through the activation … B cells from N-WASP conditional knockout mice exhibit …

… the B-cell-specific promoter mb1. Here we show that deletion of N-WASP in B cells impairs
B-cell activation and T-cell-… manifestations of immune dysregulation seen in B/WcKO mice. …

… remodeling is critical for the initiation and regulation of the … CD23 in the negative regulation
of BCR signaling induced by … CD23 can exert its negative regulatory function without being …

… is not required by B cell during antigen recognition (7), so … that during BCR signaling
attenuation, neural WASP (N-WASP), … Abp1 was found negatively regulate T-cell signaling through …

… an important study highlighting a distinct role of WASP dependent actin foci in B cell antigen
receptor signalling… SHIP-1 and SHP-1 negatively regulate BCR signaling by inactivating the …

… in the context of immune receptor signaling. The binding of … B cells are an important component
of the adaptive immune … , we hypothesized that N-WASP mediated actin regulation will …

… A key contribution of B cells to development … B cell responses remain T cell dependent in
constitutive WASp-deficient mice, whereas selective WASp deletion in germinal center B cells (…

… BCR signaling is essential for normal B cell development and … N-WASP.66 This mechanism
may also be related to the … In mIgM-expressing B cells, Grb2 is a negative regulator that …