The NADPH oxidase and the phagosome

H Valenta, M Erard, S Dupré-Crochet… - … Biology of Phagocytosis, 2020 - Springer
… The NADPH oxidase actively produces ROS only when these … events that control NADPH
oxidase activation in more detail … The assembly triggers NADPH oxidase activation and the …

NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits

SA Belambri, L Rolas, H Raad… - European journal of …, 2018 - Wiley Online Library
phagocyte NADPH oxidase. This is a multicomponent enzyme system that becomes active
after assembly of … The active NADPH oxidase is assembled at the membrane by the binding of …

Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance

GT Nguyen, ER Green, J Mecsas - Frontiers in cellular and infection …, 2017 - frontiersin.org
… In section “Assembly and Activation of NADPH Oxidase,” we … This can occur through a
number of mechanisms, the studies … of NADPH oxidase activation in PMNs and other phagocytic

Structure of human phagocyte NADPH oxidase in the resting state

R Liu, K Song, JX Wu, XP Geng, L Zheng, X Gao… - Elife, 2022 - elifesciences.org
Activation and assembly of the NADPH oxidase: a structural perspective. The Biochemical
Journal 386:401–416. DOI: https://doi.org/10.1042/BJ20041835, PMID: 15588255 Guo W, …

Membrane dynamics and organization of the phagocyte NADPH oxidase in PLB-985 cells

J Joly, E Hudik, S Lecart, D Roos… - Frontiers in Cell and …, 2020 - frontiersin.org
… The number of clusters increased during frustrated phagocytosis. In PLB-… do not assemble
a functional NADPH oxidase, the number of clusters remained stable during phagocytosis. …

Structure of human phagocyte NADPH oxidase in the activated state

X Liu, Y Shi, R Liu, K Song, L Chen - Nature, 2024 - nature.com
activated phagocyte NADPH oxidase is assembled from both the membrane fraction and
cytosolic factors 2 . The membrane fraction of phagocyte NADPH oxidase … the NADPH oxidase

The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling

WM Nauseef - Current opinion in immunology, 2019 - Elsevier
assembly of the NADPH oxidase in stimulated neutrophils. Shown are some of the interactions,
including those between proline rich regions (PRR) and src homology domains (SH3)…

How the phagocyte NADPH oxidase regulates innate immunity

DC Thomas - Free Radical Biology and Medicine, 2018 - Elsevier
… will focus primarily on the phagocyte NADPH oxidase but I will … While one can make the
point that reactive oxygen species … LPS installation also drove heightened NF-κB activation in …

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages

J Bagaitkar, J Huang, MY Zeng… - Blood, The Journal …, 2018 - ashpublications.org
… Here, we demonstrate that phagocytosis of AC (efferocytosis) potently activated NADPH
Upon ligation of inflammatory receptors, the NADPH oxidase complex is rapidly assembled by …

Regulation of neutrophil NADPH oxidase, NOX2: a crucial effector in neutrophil phenotype and function

MH Paclet, S Laurans, S Dupré-Crochet - … in Cell and Developmental …, 2022 - frontiersin.org
NADPH oxidase activation is triggered by phagocytosis but also by soluble stimuli. Long-lasting
NADPH oxidase … the NADPH oxidase components and their assembly mechanism, and …