… NF-κB family has essential roles in a wide range of biological … , we hypothesized that LEF1
regulated the progression of … f RNF121 expression in LEF1-altered expressing chondrocytes …

… -enhancer of activated B cells (NF-κB) and Toll-like receptor (… costal and articular chondrocytes
from ATC Lef1 fl/fl and Lef1 fl/… up-regulated in the Lef1-null chondrocytes and previously …

… binds to NF-κB (Nuclear Factor κB) thereby enhancing NF-κB … IL1β indeed regulates both
mRNA and protein expression of … expression of WNT related genes by increasing FZD10, LEF1…

… Gene expression levels were calculated by fragments per kilobase of exon per million …
7/Lymphoid Enhancer Binding Factor 1 (TCF7/LEF1) were down-regulated (labeled in green). In …

… promote the proliferation of OA chondrocytes and promote apoptosis [7… early chondrogenic
differentiation of MSCs by regulating … The protein expression of the extracellular matrix (ECM)-…

… pathways in regulating chondrocytes physiological and … or LEF1, induces MMP-1, -3, and
-13 expression and genetic … inhibition of NF-κB signaling pathway in rat articular chondrocytes. …

… the repression of receptor activator of NF‐κB ligand (RANKL) expression in hypertrophic …
low Lef1 expression in Lef1 −/− hypertrophic chondrocytes relative to Lef1 +/+ controls (Fig. …

… of gene expression, … LEF1, NF-κB, ELF3, HIF2α, and Rac1 via directly or indirectly impact
MMP-13 transcription. SIRT1 down-regulates MMP-13 expression in human OA chondrocytes, …

… chondrocytes augmented NF-κB activity and expression of … transcriptional upregulation of
Lef1 expression by NF-κB. PAMPs, … In summary, NF-κB signaling negatively regulates Wnt/β-…

… factor to regulate the target gene expression. However, for the … In mouse chondrocytes, NF-κB
activation indirectly, through … pathway transcription factor Lef1, regulated the transcriptional …