… group family that regulates gene expression by inducing … , we hypothesized that LEF1
regulated the progression of … f RNF121 expression in LEF1-altered expressing chondrocytes was …

… To examine the role of SIRT1 in regulating MMP13 in vivo we explored the expression of
this protease in an animal model, Sirt1 2/2 mice (29). We assessed 1-wk-old Sirt1 …

… the chondrocyte receives and integrates into gene expression … Of the four family members
(TCF1, TCF3, TCF4, and LEF1), … evidence that chondrocyte hypertrophy is regulated by many …

… SIRT1 directly represses LEF1 gene expression by binding its … costal and articular chondrocytes
from ATC Lef1 fl/fl and Lef1 fl/… up-regulated in the Lef1-null chondrocytes and previously …

… gene expression patterns or through post-translational modifications [33]. Chondrocyte gene
expression is regulated … of lymphoid enhancer-binding factor 1 (LEF1) and T-cell factor 1 (…

… Gene expression levels were calculated by fragments per kilobase of exon per million fragments
mapped (FPKM). The expression level of each gene … TCF7/LEF1) were down-regulated (…

… hASCs could have the potential for osteogenic, chondrogenic… LEF1 protein expression in
hASCs transfected with let-7i-3p … LEF1 protein expression in hASCs transfected with the let-7i-…

… (c) Fold-change in relative gene expression of chondrogenic, … , specifically TCF4, TCF7 and
LEF1, was assessed using qRT-… -regulated target [36], promotes chondrocyte hypertrophy …

… deficiency of circ_0037658 might dampen ADAMTS5 protein expression in CHON-001 cells,
… silencing might constrain ADAMTS5 expression in IL-1β-treated chondrocytes, and the re-…

… show expression of Lef-1 in proliferative chondrocytes) and … expression of Lef-1 in mineralized
hypertrophic chondrocytes… by regulating the number of proliferating chondrocytes and the …