Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-catenin signaling pathway

LJ Chen, BB Hu, XL Shi, MM Ren, WB Yu, SD Cen… - Archives of Oral …, 2017 - Elsevier
LEF1 and ultimately up-regulate the expression of its target … In the present study, the levels
of β-catenin, LEF1 and Cyclin … via estrogen receptor and NF-kappaB-dependent pathways …

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

Z Deng, Y Li, H Liu, S Xiao, L Li, J Tian… - Bioscience …, 2019 - portlandpress.com
regulate the expression of RUNX2 and the production of matrix metalloproteinase (MMP) 13
from chondrocytes to adjust the hypertrophic chondrocyte … -binding factor 1 (LEF1) appear to …

Role of microRNA-449a on IL-1β-induced inflammatory responses in human chondrocytes

박기원 - 2016 - ir.ymlib.yonsei.ac.kr
… The role of SIRT1 regulated by miR-449a in chondrocytes in … and anabolic genes expression
in IL-1β-induced chondrocytes. … H3 lysine 9 deacetylation to NF-kappaB-dependent gene

Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway

N Iwamoto, S Fukui, A Takatani, T Shimizu… - Arthritis research & …, 2018 - Springer
… The gene expression pattern of FLS is similar to that of … differentiation of FLS into chondrocytes,
adipocytes, muscle cells, … RNAs, which regulate gene expression post-transcriptionally by …

Aging, cell senescence, the pathogenesis and targeted therapies of osteoarthritis

XX Zhang, SH He, X Liang, W Li, TF Li… - Frontiers in …, 2021 - frontiersin.org
… induced gene expression, secretion, and enzyme activity of MMP-3 in articular chondrocytes
… on SASP secreted by senescent chondrocytes and the pathway regulating the production of …

[HTML][HTML] Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system

Z Dong, C Yang, J Tan, C Dou, Y Chen - Genes & Diseases, 2023 - Elsevier
… impairs gene expression (eg, NF-κB and Wnt target genes) … with transcription factor LEF1
and deacetylated H3K56, which … Ihh regulates chondrocyte differentiation through a negative …

DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening

D Kim, E You, J Jeong, P Ko, JW Kim, S Rhee - Scientific reports, 2017 - nature.com
… Thus, nuclear relocation of a transcription factor and/or its coactivator seems to be a
common phenomenon for gene expression induced by matrix stiffness. For c-Myb and LEF1, …

MicroRNAs as important regulators mediate the multiple differentiation of mesenchymal stromal cells

C Yang, M Luo, Y Chen, M You, Q Chen - Frontiers in Cell and …, 2021 - frontiersin.org
gene expression is also regulated accurately by miRNAs. The differentiation of MSCs regulated
… an important positive regulator of chondrocyte gene expression and represses multiple …

Molecular and Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation

P Deng - 2017 - escholarship.org
… Microarray analysis revealed that the genes regulated by … to inheritable changes in gene
expression without altering the … potential along the chondrogenic and osteogenic lineages but …

[HTML][HTML] MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression

J Chen, Z Liu, H Sun, M Liu, J Wang, C Zheng… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
… -203a-3p expression in primary rat chondrocytes treated with … MYD88 mRNA expression
in primary rat chondrocytes … the protein expression of MYD88 in primary rat chondrocytes