[HTML][HTML] MicroRNAs as important regulators mediate the multiple differentiation of mesenchymal stromal cells
C Yang, M Luo, Y Chen, M You, Q Chen - Frontiers in Cell and …, 2021 - frontiersin.org
… gene expression is also regulated accurately by miRNAs. The differentiation of MSCs regulated
… an important positive regulator of chondrocyte gene expression and represses multiple …
… an important positive regulator of chondrocyte gene expression and represses multiple …
[HTML][HTML] SIRT1 activity orchestrates ECM expression during hESC‐chondrogenic differentiation
CA Smith, PA Humphreys, N Bates, MA Naven… - The FASEB …, 2022 - ncbi.nlm.nih.gov
… in regulating aggrecan and collagen type‐II expression during … by which it regulates these
key chondrogenic genes and its … induced chondrogenic gene expression in 3D pellets, we …
key chondrogenic genes and its … induced chondrogenic gene expression in 3D pellets, we …
[PDF][PDF] metalloproteinases [version 1; peer review: 2 approved]
… IL-1 activated Wnt signalling and induced LEF1 levels to … ) post-transcriptionally regulate
gene expression, and numerous … and NFkappaB transcription factors in articular chondrocytes. …
gene expression, and numerous … and NFkappaB transcription factors in articular chondrocytes. …
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture
… regulated sclerostin and up-regulated DMP1 protein level and increased LEF1 and DMP1
mRNA expressions … apoptosis in chondrocytes via repressing protein tyrosine phosphatase 1B …
mRNA expressions … apoptosis in chondrocytes via repressing protein tyrosine phosphatase 1B …
Circ_SPG11 plays contributing effects on IL-1β-induced chondrocyte apoptosis and ECM degradation via miR-665 inhibition-mediated GREM1 upregulation
X Ouyang, Y Ding, L Yu, F Xin, X Yang, X Liu… - Clinical Immunology, 2021 - Elsevier
… regulated miR-665 expression. Inhibition of miR-665 reversed the inhibitory effect on IL-1β-induced
chondrocyte … We depleted circ_SPG11 expression in IL-1β-treated chondrocytes and …
chondrocyte … We depleted circ_SPG11 expression in IL-1β-treated chondrocytes and …
[HTML][HTML] Knockdown of Circ_0037658 alleviates IL-1β-induced osteoarthritis progression by serving as a sponge of miR-665 to regulate ADAMTS5
N Li, Y Wang, X Wu - Frontiers in Genetics, 2022 - frontiersin.org
… deficiency of circ_0037658 might dampen ADAMTS5 protein expression in CHON-001 cells,
… silencing might constrain ADAMTS5 expression in IL-1β-treated chondrocytes, and the re-…
… silencing might constrain ADAMTS5 expression in IL-1β-treated chondrocytes, and the re-…
[HTML][HTML] Phosphoproteomics reveals the BRAF-ERK1/2 axis as an important pathogenic signaling node in cartilage degeneration
Y Dong, P Wang, M Zhang, L Xiao, Y Yang… - Osteoarthritis and …, 2022 - Elsevier
… expression of BRAF, ERK1/2, and p-ERK1/2 in chondrocytes … expression of collagen X and
MMP-13 mRNA expression … induces chondrocytes VCL mRNA up-regulated expression 40 . …
MMP-13 mRNA expression … induces chondrocytes VCL mRNA up-regulated expression 40 . …
[HTML][HTML] Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review
HY Guo, MK Guo, ZY Wan, F Song… - Arthritis Research & …, 2020 - Springer
… reported (148 in chondrocytes and 104 in osteocytes) [95]. … They regulate gene expression
or control the signaling … a role as a competitor to LEF1 for binding miR-22, regulating Wnt/β-…
or control the signaling … a role as a competitor to LEF1 for binding miR-22, regulating Wnt/β-…
GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis
T Maruyama, D Hasegawa, T Valenta, J Haigh… - Science …, 2022 - science.org
… the expression of osteoblast (B) and chondrocyte (C) genes associated with the β-catenin
mutations identified by gene expression … known to be directly regulated by β-catenin–LEF/TCF–…
mutations identified by gene expression … known to be directly regulated by β-catenin–LEF/TCF–…
[HTML][HTML] Single-cell RNA landscape of osteoimmune microenvironment in osteoporotic vertebral compression fracture and Kümmell's disease
Y Xu, S Huang, Z Li, L Dai, H Wu, P Wang… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
… , fibroblasts, and chondrocytes were combined to reconstruct … multipotent properties such
as regulating immunity, inflammatory … , we suggest that the activation of MAPK and NF-kappaB …
as regulating immunity, inflammatory … , we suggest that the activation of MAPK and NF-kappaB …