[HTML][HTML] Natural killer cell dysfunction in hepatocellular carcinoma: pathogenesis and clinical implications

PS Sung, JW Jang - International journal of molecular sciences, 2018 - mdpi.com
… In this manner, NK cell function is regulated by a dynamic balance between signals … to
HBV clearance during acute HBV infection [69]. However, in chronic HBV infection, NK cells are …

Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy

P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
… the NK cell phenotypic and functional changes in liver disease … The functions of NK cells are
strictly regulated by the balance … The phenotype of NK cells between HBV and HCV patients …

[HTML][HTML] Liver-infiltrating CD11b− CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor …

QF Zhang, WW Yin, Y Xia, YY Yi, QF He… - Cellular & molecular …, 2017 - nature.com
… Patients infected with hepatitis B (HBV) or hepatitis C virus have … hepatocellular carcinoma
(HCC), and chronic HBV infection … This ability of NK cells depends on the delicate balance

Relationship between chronic hepatitis B virus infection and nature killer cells

J Zhang, Q Chen, H Feng - Viral Immunology, 2019 - liebertpub.com
NK cells and different clinical stages of chronic HBV infection … or hepatocellular carcinoma,
while the frequency of NK cellscell function, modulating the balance of activity and inhibitory …

[HTML][HTML] Role of immune cells in patients with hepatitis B virus-related hepatocellular carcinoma

HJ Cho, JY Cheong - International Journal of Molecular Sciences, 2021 - mdpi.com
… accepted that HBV infection induces the dysfunction of the … in NK cells obtained from
patients with HBV-related HCCHCC may be caused by the immune imbalance induced by …

… NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of patients with hepatitis B virus‐related hepatocellular carcinoma

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu… - Hepatology …, 2023 - Wiley Online Library
… a virus-infected tumor environment, the imbalance between … of NK cells in the peripheral
blood of patients with HBV-HCC. … /NKG2D on NK cells is closely related to disease progression…

[HTML][HTML] Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches

SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
HBV infection and HCV infection the frequencies of NK cells … The functions of NK cells are
strictly regulated by the balance … + NK cells in the human liver indicates deteriorating disease

[HTML][HTML] HBV-induced immune imbalance in the development of HCC

Y Chen, Z Tian - Frontiers in immunology, 2019 - frontiersin.org
… with disease progression in HBV-related HCC patients (46). … cells was demonstrated to be
significantly less in HCC tumor … of NK cell functions during the progression of HBV infection. …

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

C Sun, J Xu, Q Huang, M Huang, H Wen… - …, 2017 - Taylor & Francis
… NKG2A expression in NK cells in both chronic hepatitis B virus (HBV) patients and a … NK
cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

[PDF][PDF] Human CD96 correlates to natural killer cell exhaustion and predicts the prognosis of human hepatocellular carcinoma

H Sun, Q Huang, M Huang, H Wen, R Lin… - …, 2019 - Wiley Online Library
… the immune balance between three receptors in healthy hepatic NK cells is disrupted … NK
cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma