… NLRX1 acts as a tumor suppressor by modulating TNF-α-… and metabolic adaptation of cancer
cell, we hypothesized that … TNF-alpha induced apoptosis and metabolism in cancer cells” …

… and others have shown that NLRX1 localizes to mitochondria and regulates its metabolic …
Previously, we and others, reported that NLRX1 acts as a tumor suppressor as its expression …

… , NLRX1 silencing increased IL-1β, IL-6 and TNF-α … functions as a tumor suppressor that
promotes cancer cell apoptosis … the precise role of NLRX1 in regulating apoptosis may be …

… epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 … induced apoptosis and
metabolism in cancer cells. … Pleiotropic functions of TNF-α in the regulation of the intestinal …

… sensors/receptors that regulate immunity. This work shows that NLRX1 serves as a tumor
suppressor in colitis-associated cancer (CAC) and sporadic colon cancer by keeping key …

… NLRX1 in regulating critical hallmarks of pancreatic cancer … , and TNF-induced apoptosis
(28, 30–32, 37, 38). Conversely, … of NLRX1 with the mitochondria through metabolic and …

… role in metabolic regulation, the function of NLRX1 in diseases linked … cells where NLRX1
was deemed essential for TNF-α-… the regulatory links between NLRX1 as a tumour suppressor …

… Meanwhile, NLRX1 was present as a tumor suppressor … metabolism and lysosomal function
and as a regulator of … in DSS-induced colitis in mice by inhibiting IL-1β and TNF-α release …

… or metabolic profile of the given cell type. Here we review the … that NLRX1 can sensitize
HEK293 cells to TNF-α-induced … cells and suggest that NLRX1 mediates tumor suppression …

… ) factor that induces apoptosis through the Tom40 pathway. … In summary, the role of NLRX1
in metabolism has attracted … NLRX1 to inhibit the production of TNF-α, IL-6 and IL-1 [12], […