Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
… of viruses to tissues and cells, we construct an efficient oral Nano-DDS … mimicking both the
structure and function of viruses. We first prepare mesoporous silica NPs with nanoscale virus-…

Bio-inspired engineering of cell-and virus-like nanoparticles for drug delivery

A Parodi, R Molinaro, M Sushnitha, M Evangelopoulos… - Biomaterials, 2017 - Elsevier
… here an overview of virus- and cell-derived biomimetic delivery systems that combine the …
This mimicking of the surface topology of viruses bestowed nanoparticles with increased

Why synthetic virus-like nanoparticles can achieve higher cellular uptake efficiency?

J Li, J Wang, Q Yao, T Li, Y Yan, Z Li, J Zhang - Nanoscale, 2020 - pubs.rsc.org
… by mimicking the spiky surfaces of viruses; however, little is … as oral delivery vectors
with enhanced delivery efficiency. The … on how the virus-like surface topology affects NP–bilayer …

Advances in nanoparticle development for improved therapeutics delivery: nanoscale topographical aspect

RK Singh, JC Knowles, HW Kim - Journal of tissue …, 2019 - journals.sagepub.com
… nm) Virus-mimicking rough surface To enhance both absorptions of biomolecules and cellular
uptake Influence of nanoscale surface … The virus mimicking surface topography was also …

Carrier-free nanodrug-based virus-surface-mimicking nanosystems for efficient drug/gene co-delivery

X Sun, M Li, Y Yang, H Jia, W Liu - Biomaterials science, 2018 - pubs.rsc.org
surface of virus, which has been identified to favor cellular … -viral nanoparticle mimicking
virus surface topography. It was demonstrated that the nanoscale surface roughness enhanced

Spiky nanostructures with geometry-matching topography for virus inhibition

C Nie, M Stadtmüller, H Yang, Y Xia, T Wolff… - Nano …, 2020 - ACS Publications
better to virions than smooth nanoparticles, due to the … virus replication at the cellular nontoxic
dosage. We predict that such a combination of geometry-matching topography and cellular

Facile synthesis of uniform virus-like mesoporous silica nanoparticles for enhanced cellular internalization

W Wang, P Wang, X Tang, AA Elzatahry… - ACS central …, 2017 - ACS Publications
… a rough structure mimicking the spike proteins of a virus. The … virus-like rough surface, the
mesoporous silica nanoparticlesnanoparticles (28%), suggesting excellent drug delivery

Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023 - nature.com
Virus-inspired topographical nanoneedles can improve … may better mimic the nanoneedle
injectors of natural viruses, … For example, virus-inspired mesoporous silica nanoparticles

Virus spike and membrane-lytic mimicking nanoparticles for high cell binding and superior endosomal escape

S Liu, J Yang, H Jia, H Zhou, J Chen… - ACS applied materials & …, 2018 - ACS Publications
… for gene therapy have attracted increasing attention because viral … , such as capsid, surface
topography, and nucleic acid … -disruptive virus mimic for gene delivery. Bioreducible cross-…

Biomimetic nanomaterial strategies for virus targeting: Antiviral therapies and vaccines

JA Jackman, BK Yoon, L Ouyang… - Advanced Functional …, 2021 - Wiley Online Library
… vi) Biomimetic nanoparticle vaccines that mimic the … , targeted delivery, and/or improved
safety of viral replication inhibitors… A virus (IAV) particle based on geometry-matching topology. f) …