The impact of intrauterine growth restriction and prematurity on nephron endowment

MR Sutherland, MJ Black - Nature Reviews Nephrology, 2023 - nature.com
renal filtration surface area, and therefore diminished renal … susceptibility to the later
development of kidney disease. … capillary growth compared with that of unventilated control sheep

Renal morphology and glomerular capillarisation in young adult sheep born moderately preterm

MR Sutherland, W Malik, VB Nguyen, V Tran… - … Origins of Health and …, 2021 - cambridge.org
… length, surface area and total renal filtration surface area in the … length and surface area,
and the morphology of the kidneys, in … on nephron endowment in the preterm baboon kidney. …

[PDF][PDF] The effects of preterm birth and intrauterine growth restriction on kidney development and renal function in the neonate

D Vojisavljevic - 2016 - scholar.archive.org
… reduced total renal filtration surface area when compared to … kidney, which likely reflects a
reduced nephron endowment. … on glomerular capillary growth in the neonatal lamb kidney. J …

Preterm birth and ventilation decrease surface density of glomerular capillaries in lambs, regardless of postnatal respiratory support mode

E Staub, MJ Dahl, C Yost, S Bowen, T Aoki, A Blair… - Pediatric …, 2017 - nature.com
… , intrauterine and extrauterine growth restriction, and fluid … in sheep (~120 d gestation)
decreases nephron endowment (… and surface area, and reduced total renal filtration surface area. …

Structural and functional changes in the kidney caused by adverse fetal and neonatal environments

M Awazu - Molecular Biology Reports, 2022 - Springer
growth restriction (IUGR), the followingdevelopment was reported to be altered in preterm
sheep. Thus glomerular capillary length, surface area, and total kidney filtration surface area

Physiology and pathophysiology of compensatory adaptations of a solitary functioning kidney

Z McArdle, MF Schreuder, KM Moritz… - Frontiers in …, 2020 - frontiersin.org
… and an increase in single nephron glomerular filtration rate (… suggest that the total nephron
endowment in congenital SFK … In sheep with congenital SFK, the renal responses to systemic …

[HTML][HTML] Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

PI Good, L Li, HA Hurst, IS Herrera, K Xu, M Rao… - JCI insight, 2023 - ncbi.nlm.nih.gov
… the single-nephron glomerular filtration rate (GFR). These … While glomerular surface area
increased between 2 and 6 … long-term renal adverse effects following neonatal AKI in the …

Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models

X Wang, MR Garrett - Physiological Genomics, 2017 - journals.physiology.org
Fetal nephrectomy in the sheep resulted in the remaining kidney exhibiting a 45% increase
in nephron endowment, … born very premature and after intrauterine growth retardation. J Am …

The effect of the in utero environment on nephrogenesis and renal function

KM Moritz - Kidney Development, Disease, Repair and …, 2016 - Elsevier
… causes growth restriction and results in decreased kidney … to increase filtration surface
area [137]. This compensatory … in fetal sheep kidneys at mid-gestation after global nutrient …

Programming of renal development and chronic disease in adult life

ER Lumbers, Y Kandasamy, SJ Delforce… - Frontiers in …, 2020 - frontiersin.org
… between 90 and 120 mL/min/1.73 m 2 body surface area. … Thus, oligonephropathy caused
by fetal growth restriction or in … in the development of hypertension in young sheep whose …