… It is widely used as a rodent model of multiple sclerosis (MS). … local T cell–APC interactions
that occur during autoimmune … H2M-deficient mice are defective in the processing of native …

… be removed while the ability to stimulate T-cell … worsening with partial or even complete
recovery in between. However, as the disease continues, recovery gradually becomes deficient…

… disease in the EAE model, whereas its deficiency improves the clinical signs of the disease.
… becoming a potential therapeutic target in the treatment of patients with multiple sclerosis. …

… However, MHC class I deficient animals lacking CD8 T cell … of CD4 T cell infiltration of the
CNS during experimental … model of multiple sclerosis, have identified a crucial role for CNS …

… We demonstrate here that PLP ECD -immunized B cell-deficient … capacities (IL-10-producing
Bregs 20 versus CD4 T cell-… SD Initiation and exacerbation of autoimmune demyelination …

… reveal a hitherto unknown T cell-associated protective role of type I … designing novel
therapeutic strategies for multiple sclerosis. … T regs were labeled by use of mouse regulatory T cell …

… and clinical overlap between MOGAD, multiple sclerosis (MS), and … Interestingly,
epitope-specific T cell functional avidity help … In contrast, low T cell and high MOG ab titer induced …

… , antigen presentation, and regulatory T cell (Tregs) maintenance … Ia-restricted
neuroantigen-specific “autoregulatory” CD8+ T … The inhibition of the above pathways leads to …

… have been investigated in multiple sclerosis as potential targets of the T-cell and B-… CD8
+ -deficient mice were shown to be resistant to the development of EAE, suggesting that CD8 …

… the generation and exacerbation of MS, possibly through the … regulatory function of CD8 +
T cells. As mentioned above, one possible mechanism that is regulating CD8 + T cell function …