Mechanisms of action of glatiramer acetate in the treatment of multiple sclerosis

W Sheremata, Y Campos - Multiple Sclerosis, 2016 - Elsevier
… GA exhibits competitive inhibition of antigen presentation and further T cell activation, by …
role for CD8 + T cells has been well defined. Also, GA is able to induce regulatory T cell CD8

Preclinical models of multiple sclerosis: advantages and limitations towards better therapies

A Didonna - Current medicinal chemistry, 2016 - ingentaconnect.com
… However, the apparently contradictory observation of mice deficient of the IL12 small … litis
via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J. …

Interleukin-17 in chronic inflammatory neurological diseases

J Milovanovic, A Arsenijevic, B Stojanovic… - Frontiers in …, 2020 - frontiersin.org
… chronic neuroinflammatory conditions, multiple sclerosis (MS), … attenuated EAE, without
exacerbation after exposure to a … (234), but γδ T-cell-deficient mice still develop brain injury after …

[HTML][HTML] IL-3 promotes the development of experimental autoimmune encephalitis

K Renner, S Hellerbrand, F Hermann, C Riedhammer… - JCI insight, 2016 - ncbi.nlm.nih.gov
… Little is known about the role of IL-3 in multiple sclerosis (MS) … After adoptive transfer of
an encephalitogenic T cell clone into … The impaired function of monocytes in GM-CSF–deficient

Suppression of experimental autoimmune encephalomyelitis by ILT3. Fc

Z Xu, CC Lin, S Ho, G Vlad… - The Journal of …, 2021 - journals.aai.org
… century as the murine model of multiple sclerosis (MS) (13–15… Effect of CD8 T cell depletion
from spleen cell suspensions. (… -CD6 Ab and exacerbating the disease in CD6-KO mice (26). …

Role of immune cells migrating to the ischemic brain

AM Planas - Stroke, 2018 - Am Heart Assoc
… the role of monocytes, several studies used CCR2-deficient … invariant T-cell receptor
could play a role in acute ischemic … for remitting-relapsing multiple sclerosis that sequesters …

The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?

T Carandini, M Cercignani, D Galimberti… - Brain, Behavior, and …, 2021 - Elsevier
… in healthy subjects and multiple sclerosis (schematic). a) In … and modulate CD4+ T cell
responses in a paracrine manner (not … b) In multiple sclerosis dopaminergic dysregulation occur at …

[HTML][HTML] Aging and neurodegenerative disease: is the adaptive immune system a friend or foe?

K Mayne, JA White, CE McMurran, FJ Rivera… - Frontiers in aging …, 2020 - frontiersin.org
… However, in other CNS diseases such as multiple sclerosis, stroke… in mice deficient or depleted
of either CD4 + or CD8 + T cells… the role of both humoral and cytotoxic T cell responses in …

Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy.

M Melnikov, A Sviridova, V Rogovskii, A Oleskin… - Multiple Sclerosis and …, 2021 - Elsevier
… 5-HT 3 -receptor is probably involved in T-cell activation, as tropisetron, an antagonist of
the … , probably, is the local tryptophan deficiency. That can lead to the deficiency of 5-HT, N-…

IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes

MP Crawford, N Borcherding, NJ Karandikar - PloS one, 2023 - journals.plos.org
… Sorted CD8 T-cells and CD4 + T-cell populations were frozen in human serum and dimethyl
… [17], while upregulation of IL-17A, but not IL-17F have been noted in multiple sclerosis brain …