RNA-binding proteins balance brain function in health and disease

R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
… This review summarizes our current understanding of the complex network of RNA-binding
proteins and how they balance neuronal transmission and synaptic plasticity. We also …

RNAbinding proteins implicated in neurodegenerative diseases

MR Cookson - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
… of RNA species that are affected in these disorders suggests … of RNA species, although why
some groups of neurons are … in RNA binding proteins and, as a corollary, that neurons are …

Control of CNS functions by RNA-binding proteins in neurological diseases

Y Zhou, F Dong, Y Mao - Current pharmacology reports, 2018 - Springer
RNA-binding proteins (RBPs) are critical in regulating these processes (Fig. 1). Dysfunction
of RBPs in the early stages of neural system development may affect neuronaldiseases [1]. …

RNA-binding proteins in neurodegeneration: mechanisms in aggregate

EG Conlon, JL Manley - Genes & development, 2017 - genesdev.cshlp.org
… (Left) Approximate sites of pathology and degenerating neurons in diseases covered in
this review, including amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia type 36 (SCA36)…

RNA-binding proteins in neurological development and disease

S Prashad, PP Gopal - RNA biology, 2021 - Taylor & Francis
… stabilization in neurodevelopment and establishing neural … and other RNA-binding proteins
in the regulation of neural … of neural microexons, their regulation by RNA-binding proteins

RNA-binding proteins with prion-like domains in health and disease

AF Harrison, J Shorter - Biochemical Journal, 2017 - portlandpress.com
neurons [15,30]. Among the proteins that have been genetically linked to these diseases
and identified in cytoplasmic inclusions in patient neurons are several RNA-binding proteins (…

Neurodegeneration and RNAbinding proteins

L De Conti, M Baralle, E Buratti - … Reviews: RNA, 2017 - Wiley Online Library
… in different neurodegenerative disorders. In the next … neurons may be connected with
neurodegenerative disease. Loss of neurons is the central event in neurodegenerative diseases. …

[HTML][HTML] The emerging role of the RNA-binding protein SFPQ in neuronal function and neurodegeneration

YW Lim, D James, J Huang, M Lee - International journal of molecular …, 2020 - mdpi.com
RNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA
biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation in …

RNA Binding Proteins in Health and Disease

TE Vanderweyde, B Wolozin - Neuroimmune Pharmacology, 2017 - Springer
… other motor neuron disorders have thrust a class of proteins, termed RNA binding proteins
(… A striking number of mutations linked to motor neuron diseases occur in RBPs. The reason …

[HTML][HTML] RNA-binding proteins hold key roles in function, dysfunction, and disease

S Kelaini, C Chan, VA Cornelius, A Margariti - Biology, 2021 - mdpi.com
… the onset of the disease [63,64]. In the case of SMA, a serious motor neuron disease, small
… Survival of Motor Neuron 2 (SMN2) by binding to the gene’s pre-mRNA and increasing the …